ReviewTrends in endocrinology and metabolism: TEM2024
A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: the MiSBIE study.
Abstract readReview
In one paragraph
Review in Trends in endocrinology and metabolism: TEM, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Psychobiological and Metabolic Correlates of Time Perception in Humans: An Exploratory Study.Psychophysiology · 2026Article
- Lifetime adversity exposure, mood symptoms, and immune mitochondrial bioenergetics.medRxiv : the preprint server for health sciences · 2026Article
- Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.Research square · 2026Article
- Saliva cell-free mitochondrial DNA (cf-mtDNA) response during physical and cognitive stress.medRxiv : the preprint server for health sciences · 2026Article
- Molecular and cellular correlates of human cortical lateralization.Communications biology · 2026Article
- Individualised mapping of living human brain mitochondria by MRI reveals signatures of bioenergetic defects.bioRxiv : the preprint server for biology · 2026Article
- Immune Cell Mitochondrial Phenotypes Are Largely Preserved in Mitochondrial Diseases and Do Not Reflect Disease Severity.Neurology. Genetics · 2026Article
- Examining saliva proteomic dynamics in mitochondrial diseases from a perspective of intrinsic health.Scientific reports · 2025Article
- The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms.Neuroscience and biobehavioral reviews · 2025Review
- Mitochondrial respiratory activity and DNA damage in peripheral blood mononuclear cells in borderline personality disorder.Psychological medicine · 2025Article
- The molecular and cellular underpinnings of human brain lateralization.bioRxiv : the preprint server for biology · 2025Article
- Biopsychosocial correlates of resting and stress-reactive salivary GDF15: preliminary findings.Brain, behavior, and immunity · 2025Article
- Mitochondrial and psychosocial stress-related regulation of FGF21 in humans.Nature metabolism · 2025Article
- Next-generation oncology: integrative therapeutic frontiers at the crossroads of precision genomics, immuno-engineering, and tumor microenvironment modulation.Medical oncology (Northwood, London, England) · 2025Review
- Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress.Psychoneuroendocrinology · 2025Article
- Mitochondrial Energy Transformation Capacity Influences Brain Activation During Sensory, Affective, and Cognitive Tasks.bioRxiv : the preprint server for biology · 2025Article
- The mitochondrial disease biomarker GDF15 is dynamic, quantifiable in saliva, and correlates with disease severity.Molecular genetics and metabolism · 2025Article
- The Big Minority View: Do Prescientific Beliefs Underpin Criminal Justice Cruelty, and Is the Public Health Quarantine Model a Remedy?International journal of environmental research and public health · 2025Article
- The energetic stress cytokine GDF15 is elevated in the context of chronic and acute psychosocial stress.bioRxiv : the preprint server for biology · 2025Article
- Intrinsic health as a foundation for a science of health.Science advances · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
48 authors.
Catherine KellyDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Caroline TrumpffDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Carlos AcostaDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Stephanie AssurasDepartment of Clinical Neuropsychology, Division of Cognitive Neuroscience, Columbia University Irving Medical Center, New York, NY, USA.
Jack BakerDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Sophia BasarrateDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Alexander BehnkeDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA; Clinical and Biological Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.
Ke BoDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.
Natalia Bobba-AlvesDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Frances A ChampagneDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Quinn ConklinDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Marissa CrossDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Philip De JagerCenter for Translational and Computational Neuroimmunology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Kris EngelstadH. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Elissa EpelWeill Institute for Neurosciences, Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Soah G FranklinDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Michio HiranoH. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Qiuhan HuangDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Alex JunkerDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Robert-Paul JusterDepartment of Psychiatry and Addiction, University of Montreal, Montreal, Quebec, Canada.
Darshana KapriDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Clemens KirschbaumFaculty of Psychology, Institute of Biopsychology, Technical University Dresden, Dresden, Germany.
Mangesh KuradeDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Vincenzo LauriolaDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Shufang LiH. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Cynthia C LiuDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Grace LiuDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Bruce McEwenLaboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA.
Marlon A McGillDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Kathleen McIntyreDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Anna S MonzelDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Jeremy MichelsonDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Aric A PratherWeill Institute for Neurosciences, Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Eli PutermanSchool of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada.
Xiomara Q RosalesH. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Peter A ShapiroDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA; Consultation-Liaison Psychiatry, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
David ShireDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
George M SlavichDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Richard P SloanDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Janell L M SmithDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Marisa SpannDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Julie SpicerDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gabriel SturmDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Sophia TeplerDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.
Michel Thiebaut de SchottenBrain Connectivity and Behavior Laboratory, Paris, France; Groupe d'Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA University of Bordeaux, Bordeaux, France.
Tor D WagerDepartment of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA.
Martin PicardDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA; H. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA; Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA. Electronic address: martin.picard@columbia.edu.
MiSBIE Study Group
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MClinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0MMitochondrial regulation of stress reactivity in humansR01MH122706 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2020 to 2024
$3.8MTransduction of Psychological Stress into Systematic Inflammation by Mitochondrial DNA SignalingR01MH119336 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KAUFMAN, BRETT A, MARSLAND, ANNA L · 2019 to 2023
$3.4MMitochondrial Energetics, Circuits and Cognitive Decline in the Aging Human BrainRF1AG076821 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2022 to 2022
$2.4MPsychobiological regulation and molecular characterization of cell-free mitochondrial DNA in humansR01MH137190 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Martin Picard, Caroline Trumpff · 2024 to 2026
$2.4MMitochondrial Regulation of Stress Reactivity in HumansR21MH113011 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2017 to 2018
$440kPsychobiological Regulation of Cell-Free Mitochondrial DNA in Human SalivaR21MH123927 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2021 to 2022
$405kNCATS NIH HHS UL1 TR001873NCI NIH HHS P30 CA013696NIA NIH HHS RF1 AG076821NIMH NIH HHS R01 MH119336NIMH NIH HHS R01 MH122706NIMH NIH HHS R01 MH137190NIMH NIH HHS R21 MH113011NIMH NIH HHS R21 MH123927
Abstract
Health emerges from coordinated psychobiological processes powered by mitochondrial energy transformation. But how do mitochondria regulate the multisystem responses that shape resilience and disease risk across the lifespan? The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was established to address this question and determine how mitochondria influence the interconnected neuroendocrine, immune, metabolic, cardiovascular, cognitive, and emotional systems among individuals spanning the spectrum of mitochondrial energy transformation capacity, including participants with rare mitochondrial DNA (mtDNA) lesions causing mitochondrial diseases (MitoDs). This interdisciplinary effort is expected to generate new insights into the pathophysiology of MitoDs, provide a foundation to develop novel biomarkers of human health, and integrate our fragmented knowledge of bioenergetic, brain-body, and mind-mitochondria processes relevant to medicine and public health.
Indexed as
MitochondriaBrainDNA, MitochondrialHumansMitochondrial DiseasesDNA, Mitochondrialallostasismetabolismmitochondrial disordersmtDNApsychobiologystress
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.