Evidence map›Paper›PMID 39389597›Full record

Observational studyBMJ open2024

Longitudinal frailty assessment in the prediction of survival among patients with advanced chronic kidney disease: a prospective observational single-centre cohort study.

Alice Kennard, Alice Richardson, Suzanne Rainsford, Kelly Hamilton, Nicholas Glasgow, Kate Pumpa, Angela Douglas, Girish Scricant Talaulikar

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alice KennardCollege of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia alice.kennard@act.gov.au.ORCID http://orcid.org/0000-0002-4745-7206
Alice RichardsonAustralian National University, Canberra, Canberra, Australia.ORCID http://orcid.org/0000-0001-7084-1524
Suzanne RainsfordCollege of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia.
Kelly HamiltonDepartment of Renal Medicine, Canberra Hospital, Canberra, Australian Capital Territory, Australia.
Nicholas GlasgowCollege of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia.
Kate PumpaUniversity College Dublin, Dublin, Ireland.
Angela DouglasUniversity of Canberra, Canberra, Canberra, Australia.
Girish Scricant TalaulikarCollege of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to describe the prevalence, characteristics and longitudinal changes in frailty among outpatient chronic kidney disease (CKD) and haemodialysis (HD) populations and their impact on survival.

designProspective observational cohort study.

settingSingle-centre ambulatory tertiary care setting, metropolitan Australian teaching hospital.

participantsAdult patients with advanced CKD (defined as estimated glomerular filtration rate <20 mL/min) or undergoing maintenance HD. Consent model was informed opt-out consent.

interventionsFried frailty assessment at baseline, 6 months and 12 months of longitudinal follow-up. PRIMARY OUTCOMES: All-cause mortality and kidney transplantation events.

resultsFrailty was identified in 36.3% of the 256 participants, while an additional 46.5% exhibited prefrailty. Frailty was equally common among CKD and HD cohorts. Frailty outperformed age, comorbidity and laboratory parameters in predicting mortality risk with HR 2.83 (95% CI 1.44 to 5.56, p<0.001). Frailty also substantially reduced access to transplantation. While most participants exhibited static Fried phenotype over longitudinal assessment, improvements in frailty were observed as frequently as frailty progression. Female gender and symptom burden predicted frailty progression.

conclusionsFrailty is highly prevalent and closely aligned with survival outcomes. Frailty among patients attending routine outpatient care may demonstrate responsiveness to intervention with subsequent improvements in mortality and other patient-level outcomes.

Indexed as

FrailtyRenal DialysisRenal Insufficiency, ChronicAgedAustraliaFemaleGlomerular Filtration RateHumansKidney TransplantationLongitudinal StudiesMaleMiddle AgedPrevalenceProspective StudiesDialysisFrailtyKidney & urinary tract disordersMortalityTransplant medicine

Identifiers

PMID39389597
PMCPMC11474908

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.