SynthesisBiological psychiatry2025
Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders.
Synthesis in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global bibliometric analysis of Tourette syndrome research (1960-2024): trends, collaborations and emerging themes.Frontiers in neurology · 2025Pooled it
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Whole-exome sequencing in individuals with obsessive-compulsive disorder and chronic tic disorders identifies 36 large-effect risk genes.Nature neuroscience · 2026Article
- Proneness to infections and familial risk of tic disorders.Psychological medicine · 2026Article
- Tourette disorder features pervasive neuronal and glial transcriptional remodeling in the dorsolateral prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Rare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders.medRxiv : the preprint server for health sciences · 2025Article
- Shared genetic architecture between anxiety, depression and erectile dysfunction: a genome-wide cross-trait analysis.Translational andrology and urology · 2025Article
- Advances in Clustering and Classification of Tic Disorders: A Systematic Review.Neuropsychiatric disease and treatment · 2024Review
Corrections and comments
- Erratum issuedErratum.2025
Authors and funding
26 authors.
Funding
Abstract
backgroundDespite the significant personal and societal burden of tic disorders (TDs), treatment outcomes remain modest, necessitating a deeper understanding of their etiology. Family history is the biggest known risk factor, and identifying risk genes could accelerate progress in the field.
methodsExpanding upon previous sample size limitations, we added 4800 new TD cases and 971,560 controls and conducted a genome-wide association study (GWAS) meta-analysis with 9619 cases and 981,048 controls of European ancestry. We attempted to replicate the results in an independent deCODE genetics GWAS (885 TD cases and 310,367 controls). To characterize GWAS findings, we conducted several post-GWAS gene-based and enrichment analyses.
resultsA genome-wide significant hit (rs79244681, p = 2.27 × 10
conclusionsThis GWAS was still underpowered to identify high-confidence, replicable loci, but the results suggest imminent discovery of common genetic variants for TDs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.