Evidence map›Paper›PMID 39389290›Full record

ReviewJournal of molecular biology2025

Sifting through the noise: A survey of diffusion probabilistic models and their applications to biomolecules.

Trevor Norton, Debswapna Bhattacharya

Abstract readReview
In one paragraph

Review in Journal of molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Trevor NortonDepartment of Computer Science, Virginia Tech, Blacksburg, VA 24061, United States.
Debswapna BhattacharyaDepartment of Computer Science, Virginia Tech, Blacksburg, VA 24061, United States. Electronic address: dbhattacharya@vt.edu.

Funding

GPU-accelerated high-performance computing to supercharge foundational deep learning method development for scalable and accurate prediction of protein structuresR35GM138146 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Debswapna Bhattacharya · 2020 to 2026
$2.5M
NIGMS NIH HHS R35 GM138146
6 · The paper itself

Abstract

Diffusion probabilistic models have made their way into a number of high-profile applications since their inception. In particular, there has been a wave of research into using diffusion models in the prediction and design of biomolecular structures and sequences. Their growing ubiquity makes it imperative for researchers in these fields to understand them. This paper serves as a general overview for the theory behind these models and the current state of research. We first introduce diffusion models and discuss common motifs used when applying them to biomolecules. We then present the significant outcomes achieved through the application of these models in generative and predictive tasks. This survey aims to provide readers with a comprehensive understanding of the increasingly critical role of diffusion models.

Indexed as

Models, StatisticalDiffusionbiomolecular designbiomolecular predictiondeep generative modelsdiffusion probabilistic modelsmachine learning

Identifiers

PMID39389290
PMCPMC11885034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.