Evidence map›Paper›PMID 39389032›Full record

ReviewCell host & microbe2024

Immunity to fungi and vaccine considerations.

Alexander J Whitehead, Therese Woodring, Bruce S Klein

Abstract readReview
In one paragraph

Review in Cell host & microbe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Journal of fungi (Basel, Switzerland) · 2026
    Article
  2. Fungal Infections in Disorders of Inborn Errors of Immunity.Clinical reviews in allergy & immunology · 2026
    Review
  3. Innovation in antifungal therapy.EMBO molecular medicine · 2026
    Review
  4. α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in anJournal of the American Chemical Society · 2026
    Article
  5. Review
  6. Fungal vaccines: so needed, so feasible, and yet so far off.The Journal of clinical investigation · 2025
    Article
  7. Human immunity to fungal infections.The Journal of experimental medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander J WhiteheadDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.
Therese WoodringDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.
Bruce S KleinDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: bsklein@wisc.edu.

Funding

Novel antimicrobials targeting MDR pathogens from animal microbial symbiontsU19AI142720 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SAFDAR, NASIA · 2019 to 2023
$30.1M
PROTECTIVE IMMUNE RESPONSES TO BLASTOMYCES DERMATITIDISR01AI040996 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, WUETHRICH, MARCEL · 1997 to 2023
$10.4M
Molecular Pathogenesis of BlastomycosisR37AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2004 to 2026
$6.9M
Novel Combination Adjuvant for Eliciting Systemic and Mucosal CD8 T Cell MemoryU01AI124299 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN, SURESH, MARULASIDDAPPA · 2016 to 2025
$6.2M
Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
MOLECULAR PATHOGENESIS OF BLASTOMYCOSISR01AI035681 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 1995 to 2019
$3.9M
Mechanisms of vaccine immunity against coccidioidomycosisR01AI168370 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI BRUCE Steven KLEIN · 2023 to 2026
$2.2M
Mechanisms of Vaccine Immunity against CoccidioidomycosisR56AI168370 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2022 to 2022
$489k
Cellular and molecular mechanisms involving SLAMF1 during pulmonary fungal infectionR21AI173718 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WUETHRICH, MARCEL · 2023 to 2024
$428k
NIAID NIH HHS R01 AI035681NIAID NIH HHS R01 AI040996NIAID NIH HHS R01 AI168370NIAID NIH HHS R21 AI173718NIAID NIH HHS R37 AI035681NIAID NIH HHS R56 AI168370NIAID NIH HHS T32 AI055397NIAID NIH HHS U01 AI124299NIAID NIH HHS U19 AI142720
6 · The paper itself

Abstract

Fungal disease poses a growing threat to public health that our current antifungal therapies are not well equipped to meet. As the population of immunocompromised hosts expands, and ecological changes favor the emergence of fungal pathogens, the development of new antifungal agents, including vaccines, becomes a global priority. Here, we summarize recent advancements in the understanding of fungal pathogenesis, key features of the host antifungal immune response, and how these findings could be leveraged to design novel approaches to deadly fungal disease.

Indexed as

Fungal VaccinesFungiMycosesAnimalsAntifungal AgentsHost-Pathogen InteractionsHumansImmunocompromised HostAntifungal AgentsFungal Vaccines

Identifiers

PMID39389032
PMCPMC11980782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.