ArticleCell genomics2024
Phenome-wide association study in 25,639 pregnant Chinese women reveals loci associated with maternal comorbidities and child health.
Article in Cell genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects.Nature genetics · 2026Article
- Genome Variation Map: a platform for the analysis and integration of genomic variation.Nucleic acids research · 2026Article
- Flexible read-aware genotype imputation from sequence using biobank sized reference panels.Nature communications · 2025Article
- Performance evaluation of structural variation detection using DNBSEQ whole-genome sequencing.BMC genomics · 2025Article
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17 authors.
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Abstract
Phenome-wide association studies (PheWAS) have been less focused on maternal diseases and maternal-newborn comorbidities, especially in the Chinese population. To enhance our understanding of the genetic basis of these related diseases, we conducted a PheWAS on 25,639 pregnant women and 14,151 newborns in the Chinese Han population using ultra-low-coverage whole-genome sequence (ulcWGS). We identified 2,883 maternal trait-associated SNPs associated with 26 phenotypes, among which 99.5% were near established genome-wide association study (GWAS) loci. Further refinement delineated these SNPs to 442 unique trait-associated loci (TALs) predicated on linkage disequilibrium R
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