ArticleCell genomics2024
Genetic analyses of 104 phenotypes in 20,900 Chinese pregnant women reveal pregnancy-specific discoveries.
Article in Cell genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects.Nature genetics · 2026Article
- Phenotypic subclassification of preeclampsia through cluster analysis of preterm birth-related factors.BMC medical informatics and decision making · 2026Article
- cfGWAS reveal genetic basis of cell-free DNA end motifs.Nature communications · 2026Article
- A low-coverage skim-sequencing and imputation pipeline for genomic selection.The plant genome · 2025Article
- Cell-free DNA as a potential alternative to genomic DNA in genetic studies.NAR genomics and bioinformatics · 2025Article
- Performance evaluation of structural variation detection using DNBSEQ whole-genome sequencing.BMC genomics · 2025Article
- A genome-wide association study of neonatal metabolites.Cell genomics · 2024Article
- Utilizing non-invasive prenatal test sequencing data for human genetic investigation.Cell genomics · 2024Article
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33 authors.
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Abstract
Monitoring biochemical phenotypes during pregnancy is vital for maternal and fetal health, allowing early detection and management of pregnancy-related conditions to ensure safety for both. Here, we conducted a genetic analysis of 104 pregnancy phenotypes in 20,900 Chinese women. The genome-wide association study (GWAS) identified a total of 410 trait-locus associations, with 71.71% reported previously. Among the 116 novel hits for 45 phenotypes, 83 were successfully replicated. Among them, 31 were defined as potentially pregnancy-specific associations, including creatine and HELLPAR and neutrophils and ESR1, with subsequent analysis revealing enrichments in estrogen-related pathways and female reproductive tissues. The partitioning heritability underscored the significant roles of fetal blood, embryoid bodies, and female reproductive organs in pregnancy hematology and birth outcomes. Pathway analysis confirmed the intricate interplay of hormone and immune regulation, metabolism, and cell cycle during pregnancy. This study contributes to the understanding of genetic influences on pregnancy phenotypes and their implications for maternal health.
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