Evidence map›Paper›PMID 39388845›Full record

ArticleEnvironment international2024

Serum concentrations of per- and polyfluorinated substances and risk of B-cell non-Hodgkin lymphoma.

Jongeun Rhee, Jani Koponen, Joshua N Sampson, Alexander P Keil, Mary H Ward, Jonathan N Hofmann, Wen-Yi Huang, Debra T Silverman, Panu Rantakokko, Mark P Purdue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jongeun RheeOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Rockville, MD, USA.
Jani KoponenLifestyles and Environments Unit, Finnish Institute of Health and Welfare, Kuopio, Finland.
Joshua N SampsonBiostatistics Branch, DCEG, NCI, Rockville, MD, USA.
Alexander P KeilOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Rockville, MD, USA.
Mary H WardOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Rockville, MD, USA.
Jonathan N HofmannOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Rockville, MD, USA.
Wen-Yi HuangMetabolic Epidemiology Branch, DCEG, NCI, Rockville, MD, USA.
Debra T SilvermanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Rockville, MD, USA.
Panu RantakokkoLifestyles and Environments Unit, Finnish Institute of Health and Welfare, Kuopio, Finland.
Mark P PurdueOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), Rockville, MD, USA. Electronic address: purduem@mail.nih.gov.

Funding

Cohort and Biobank DevelopmentZICCP010226 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KRAFT, PETER · 2014 to 2025
$133.4M
Studies of the Natural History of Sickle Cell DiseaseZIAHL006233 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI THEIN, SWEE LAY · 2017 to 2025
$10.9M
Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIC CP010226
6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants that are detectable in the serum of most U.S. adults. Some studies of highly-exposed individuals have suggested positive associations between PFAS and B-cell non-Hodgkin lymphoma (B-NHL). To investigate whether associations exist at lower exposure levels, we conducted a nested case-control study investigating serum PFAS concentrations and B-NHL within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. We measured pre-diagnostic serum concentrations of five PFAS among 706 cases (age at diagnosis = 55-93 years, median 73 years) and 706 controls individually matched on age at blood draw, sex, self-reported race and ethnicity, study center, and year of blood collection (the median follow-up years = 10). We estimated odds ratios (ORs) and 95 % confidence intervals (CIs) for PFAS concentrations in relation to B-NHL, both overall and for selected histologic subtypes [diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), and marginal zone lymphoma (MZL)] using conditional logistic regression. We found no evidence of a positive association with B-NHL for any of the five PFAS. In analyses of histologic subtypes, perfluorohexane sulfonate (PFHxS) was significantly associated with DLBCL in a model adjusting for all other PFAS (OR for highest vs. lowest quintile = 2.19, 95 % CI = 1.21, 3.95; P

Indexed as

FluorocarbonsAgedAged, 80 and overAlkanesulfonic AcidsCase-Control StudiesEnvironmental ExposureEnvironmental PollutantsFemaleHumansLymphoma, B-CellLymphoma, Non-HodgkinMaleMiddle AgedOdds RatioSulfonic AcidsAlkanesulfonic AcidsEnvironmental PollutantsFluorocarbonsperfluorohexanesulfonic acidSulfonic AcidsCancerDiffuse large B cell lymphomaNon-Hodgkin lymphomaPer- and polyfluoroalkyl substancesPerfluorohexane sulfonate

Identifiers

PMID39388845
PMCPMC11502238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.