Evidence map›Paper›PMID 39388662›Full record

ArticleJCO global oncology2024

Clinical and Genomic Characterization of

Sebastián Mondaca, Henry Walch, Santiago Sepúlveda, Nikolaus Schultz, Gonzalo Muñoz, Amin Yaqubie, Patricia Macanas, Claudia Pareja, Patricia Garcia, Walid Chatila and 6 more

Abstract readComparative Study
In one paragraph

Article in JCO global oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sebastián MondacaDepartment of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Henry WalchMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-1188-350X
Santiago SepúlvedaDepartment of Pathology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0002-0907-903X
Nikolaus SchultzMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-0131-4904
Gonzalo MuñozDepartment of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0002-4597-2458
Amin YaqubieDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Patricia MacanasDepartment of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0003-2631-8618
Claudia ParejaDepartment of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0002-2320-1564
Patricia GarciaDepartment of Pathology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Walid ChatilaMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-5474-218X
Bruno NerviDepartment of Hematology and Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0002-3016-7261
Bob LiDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0001-6661-8733
James J HardingDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-7029-4310
Paola VivianiDepartment of Public Health, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0003-2886-5228
Juan Carlos RoaDepartment of Pathology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0001-8313-8774
Ghassan K Abou-AlfaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-1522-8054

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeGallbladder cancer (GBC) is a biliary tract malignancy characterized by its high lethality. Although the incidence of GBC is low in most countries, specific areas such as Chile display a high incidence. Our collaborative study sought to compare clinical and molecular features of GBC cohorts from Chile and the United States with a focus on

methodsPatients were accrued at Memorial Sloan Kettering Cancer Center (MSK) or the Pontificia Universidad Católica de Chile (PUC). Clinical information was retrieved from medical records. Genomic analysis was performed by the next-generation sequencing platform MSK-Integrated Mutation Profiling of Actionable Cancer Targets.

resultsA total of 260 patients with GBC were included, 237 from MSK and 23 from PUC. There were no significant differences in the clinical characteristics between the patients identified at MSK and at PUC except in terms of lithiasis prevalence which was significantly higher in the PUC cohort (85%

conclusionThe prevalence of lithiasis seems to be higher in Chilean versus US patients with GBC. A similar prevalence of

Indexed as

Erb-b2 Receptor Tyrosine KinasesGallbladder NeoplasmsAdultAgedAged, 80 and overChileCohort StudiesFemaleGenomicsHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedMutationUnited StatesERBB2 protein, humanErb-b2 Receptor Tyrosine Kinases

Identifiers

PMID39388662
PMCPMC11487998

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.