Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
24 authors.
Eduardo A Maury *Division of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-2211-8611
Attila Jones *Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-0257-8781
Vladimir Seplyarskiy *Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-3161-8770
Thanh Thanh L NguyenDepartment of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-2281-6540
Chaggai RosenbluhDepartment of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Taejong BaeDepartment of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-4626-3725
Yifan WangDepartment of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-8056-9755
Alexej AbyzovDepartment of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-5405-6729
Sattar KhoshkhooDivision of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-3348-557X
Yasmine ChahineDivision of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.
Sijing ZhaoDivision of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-1247-6834
Sanan VenkateshDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-3094-2731
Elise RootDepartment of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.
Georgios VoloudakisCenter for Disease Neurogenomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-5729-632X
Panagiotis RoussosCenter for Disease Neurogenomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-4640-6239
Brain Somatic Mosaicism Network‡
Peter J ParkDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9378-960X
Schahram AkbarianDepartment of Psychiatry and Neuroscience, Friedman Brain Institute, Mount Sinai, New York, NY 10029, USA.ORCID 0000-0001-7700-0891
Kristen BrennandDepartment of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-0993-5956
Steven ReillyDepartment of Genetics, Yale School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-3140-1483
Eunjung A LeeDivision of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-6574-9261
Shamil R SunyaevDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5715-5677
Christopher A WalshDivision of Genetics and Genomics, Manton Center for Orphan Disease, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-0156-2238
Andrew ChessDepartment of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-4501-8816
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
RESEARCH TRAINING-MEDICAL INFORMATICS 90T15LM007092 · NLM · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Nils Gehlenborg · 1992 to 2026
$32.8M
Statistical methods for studies of rare variantsR01MH101244 · NIMH · HARVARD MEDICAL SCHOOL · PI Benjamin Michael Neale, ALKES L PRICE · 2013 to 2026
$9.4M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
1/2-Somatic mosaicism and autism spectrum disorderU01MH106883 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI PARK, PETER J, WALSH, CHRISTOPHER A. · 2015 to 2019
$9.2M
The origin, the function and the phenotypic impact of human allelesR35GM127131 · NIGMS · HARVARD MEDICAL SCHOOL · PI SHAMIL SUNYAEV · 2018 to 2026
$8.1M
Somatic Mosaicism in Schizophrenia and Control BrainsU01MH106891 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, CHESS, ANDREW J · 2015 to 2019
$7.3M
RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2M
Higher Order Chromatin and Genetic Risk for SchizophreniaR01MH106056 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, BRENNAND, KRISTEN JENNIFER · 2015 to 2023
$6.7M
Somatic Mosaicism in the Brain of Tourette SyndromeU01MH106876 · NIMH · YALE UNIVERSITY · PI VACCARINO, FLORA M · 2015 to 2019
$6.1M
Predicting the impact of genetic variants, genes and pathways on human DiseaseU01HG012009 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ALKES L PRICE, Soumya Raychaudhuri · 2021 to 2026
$4.2M
Resolving complex alternative splicing of psychiatric disease genes using single-cell approachesR01MH125579 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BRENNAND, KRISTEN JENNIFER, FANG, GANG · 2021 to 2025
Germline mutations modulate the risk of developing schizophrenia (SCZ). Much less is known about the role of mosaic somatic mutations in the context of SCZ. Deep (239×) whole-genome sequencing (WGS) of brain neurons from 61 SCZ cases and 25 controls postmortem identified mutations occurring during prenatal neurogenesis. SCZ cases showed increased somatic variants in open chromatin, with increased mosaic CpG transversions (CpG>GpG) and T>G mutations at transcription factor binding sites (TFBSs) overlapping open chromatin, a result not seen in controls. Some of these variants alter gene expression, including SCZ risk genes and genes involved in neurodevelopment. Although these mutational processes can reflect a difference in factors indirectly involved in disease, increased somatic mutations at developmental TFBSs could also potentially contribute to SCZ.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes. · full record | OpenQuestion