Evidence map›Paper›PMID 39388350›Full record

ArticleCell reports2024

WWC2 modulates GABA

Thomas L Dunham, Julia R Wilkerson, Richard C Johnson, Richard L Huganir, Lenora J Volk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Thomas L DunhamNeuroscience Graduate Program, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Julia R WilkersonDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Richard C JohnsonDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Richard L HuganirDepartment of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Lenora J VolkDepartment of Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Psychiatry UT Southwestern Medical Center, Dallas, TX 75390, USA; Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: lenora.volk@utsouthwestern.edu.

Funding

Neural function of the human memory-associated protein KIBRA: bridging molecular to circuit-level functionR01MH117149 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI VOLK, LENORA J · 2018 to 2022
$2.0M
NIMH NIH HHS R01 MH117149
6 · The paper itself

Abstract

The WW and C2 domain-containing protein (WWC2) is implicated in several neurological disorders. Here, we demonstrate that WWC2 interacts with inhibitory, but not excitatory, postsynaptic scaffolds, consistent with prior proteomic identification of WWC2 as a putative component of the inhibitory postsynaptic density. Using mice lacking WWC2 expression in excitatory forebrain neurons, we show that WWC2 suppresses γ-aminobutyric acid type-A receptor (GABA

Indexed as

Receptors, GABA-ASynapsesSynaptic TransmissionAdaptor Proteins, Signal TransducingAnimalsCell MembraneHEK293 CellsHumansIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsPyramidal CellsReceptors, AMPAAdaptor Proteins, Signal TransducingGrip1 protein, mouseIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsReceptors, AMPAReceptors, GABA-AAMPA receptorCP: Neurosciencedendritic arborizationGABAA receptorGRIP1HAP1inhibitory synapseKIBRAsynaptic transmissionWWC1WWC2

Identifiers

PMID39388350
PMCPMC11913214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.