Evidence map›Paper›PMID 39388305›Full record

ArticleAging2024

DNA methylation-driven gene FAM3D promotes colorectal cancer growth via the ATF4-SESN2-mTORC1 pathway.

Ting Zheng, Ding Zhang, Qingzhen Fu, Mingxue Wang, Zesong Cheng, Yukun Cao, Liwan Wang, Jinyin Liu, Yashuang Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ting ZhengDepartment of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Ding ZhangDepartment of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Qingzhen FuDepartment of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Mingxue WangDepartment of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Zesong ChengDepartment of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Yukun CaoDepartment of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Liwan WangDepartment of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Jinyin LiuDepartment of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China.
Yashuang ZhaoDepartment of Epidemiology, Public Health School of Harbin Medical University, Harbin, Heilongjiang, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Globally, colorectal cancer (CRC) is the malignant tumor with the highest mortality rate after lung cancer. Abnormal DNA methylation drives dysregulated gene expression, thereby promoting CRC progression and leading to poor prognosis. We identified a 3-CpG methylation signature that is independently associated with CRC prognosis. The model consists of three methylation-driven genes: FAM3 Metabolism Regulating Signaling Molecule D (FAM3D), DAPP1, and PIGR. However, the prognostic significance, biological function, and related mechanisms of the individual methylation-driven gene FAM3D in CRC have not been studied. Here, we discovered that FAM3D expression was reduced in CRC tissues and cells, and that high methylation and low expression of FAM3D were independent prognostic risk factors for CRC. In addition, FAM3D promoted the growth and movement of CRC cells

Indexed as

Cell ProliferationColorectal NeoplasmsDNA MethylationGene Expression Regulation, NeoplasticMechanistic Target of Rapamycin Complex 1Mice, NudeActivating Transcription Factor 4AnimalsCell Line, TumorFemaleHumansMaleMiceMiddle AgedPrognosisSignal TransductionActivating Transcription Factor 4Mechanistic Target of Rapamycin Complex 1colorectal cancerFAM3Dmethylation-driven genemTORC1 pathwayprognostic marker

Identifiers

PMID39388305
PMCPMC11501385

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.