Evidence map›Paper›PMID 39388249›Full record

ArticleBiology of reproduction2025

Delayed endometrial preparation for the induction of luteolysis as a potential factor for improved reproductive performance in Angus beef heifers with high antral follicle counts†.

Martim Kaps, Lacey K Quail, Shelby L Rosasco, Alexandria P Snider, Saulo M Zoca, Kaitlin M Epperson, Jerica J J Rich, Jeremy R Miles, Matthew S Crouse, Brittney N Keel and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of reproduction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Martim KapsUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.
Lacey K QuailTexas AgriLife, Overton, TX, USA.
Shelby L RosascoDepartment of Animal and Range Sciences, New Mexico State University, Las Cruces, NM, USA.
Alexandria P SniderUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.
Saulo M ZocaDepartment of Animal Science, South Dakota State University, Brookings, SD, USA.
Kaitlin M EppersonTexas AgriLife, Overton, TX, USA.
Jerica J J RichDepartment of Animal Science, South Dakota State University, Brookings, SD, USA.
Jeremy R MilesUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.
Matthew S CrouseUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.
Brittney N KeelUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.
Adam F SummersDepartment of Animal and Range Sciences, New Mexico State University, Las Cruces, NM, USA.
George A PerryTexas AgriLife, Overton, TX, USA.
Clay A LentsUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.
Robert A CushmanUSDA, ARS, U.S. Meat Animal Research Center, Clay Center, NE, USA.

Funding

ARS project 3040-31000-096DAustrian Science Fund J4690Austrian Science Fund FWF J 4690
6 · The paper itself

Abstract

Antral follicle count (AFC) and anti-Müllerian hormone (AMH) concentrations are reflective for ovarian reserve and have been associated with improved reproductive performance in cattle. Key events for regulation of uterine receptivity are orchestrated by progesterone. As progesterone concentrations are greater in animals with high than low AFC, we tested the hypothesis, if the resulting improved uterine environment will lead to improved conceptus elongation and endometrial response to interferon tau. For four years, 10 heifers with lowest and highest AFC, respectively, were selected from 120 heifers. Reproductive tracts and blood samples for progesterone and AMH analysis were collected after synchronization and insemination. For a recovered conceptus, length was determined, and interferon tau (IFNT) transcript abundance was analyzed. Endometrial transcript abundance of interferon-stimulated gene 15 (ISG15) and oxytocin receptor (OXTR) were analyzed. Progesterone concentrations did not differ between low and high AFC groups (P = 0.1). A difference in conceptus length was not observed. Endometrial abundance of ISG15 did not differ between pregnant low and high AFC heifers. Abundance of OXTR was greater in open low AFC than open high AFC heifers (P < 0.01). Interaction of AMH and pregnancy status was determined, with greater AMH in pregnant than open high AFC heifers (P < 0.05). Improved uterine environment in high vs. low AFC heifers did not result in longer conceptuses or improved endometrial response. As the increase in OXTR transcript abundance was only detected in low AFC heifers, reported differences in reproductive performance might be associated with earlier initiation of luteolysis.

Indexed as

EndometriumLuteolysisOvarian FollicleReproductionAnimalsAnti-Mullerian HormoneCattleFemaleInterferon Type IPregnancyPregnancy ProteinsProgesteroneReceptors, OxytocinAnti-Mullerian Hormoneinterferon tauInterferon Type IPregnancy ProteinsProgesteroneReceptors, Oxytocinanti-Müllerian hormoneantral follicle countconceptus elongationluteolysisoxytocin receptorprogesterone

Identifiers

PMID39388249
PMCPMC11736429

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.