ArticleJournal of pharmacokinetics and biopharmaceutics1985
A new method for assessment of drug disposition in muscle: application of statistical moment theory to local perfusion systems.
Article in Journal of pharmacokinetics and biopharmaceutics, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Understanding In Vivo Fate of Nucleic Acid and Gene Medicines for the Rational Design of Drugs.Pharmaceutics · 2021Review
- Analysis of hepatic disposition of galactosylated cationic liposome/plasmid DNA complexes in perfused rat liver.Pharmaceutical research · 2003Article
- Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors.Pharmaceutical research · 1998Article
- A physiologically based pharmacokinetic model incorporating dispersion principles to describe solute distribution in the perfused rat hindlimb preparation.Journal of pharmacokinetics and biopharmaceutics · 1997Article
- Renal disposition of recombinant human interleukin-11 in the isolated perfused rat kidney.Pharmaceutical research · 1997Article
- Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system.Pharmaceutical research · 1996Article
- Disposition characteristics of plasmid DNA in the single-pass rat liver perfusion system.Pharmaceutical research · 1996Article
- Evaluation of the uptake of pravastatin by perfused rat liver and primary cultured rat hepatocytes.Pharmaceutical research · 1995Article
- Discrepancies in pharmacokinetic parameter estimation between bolus and infusion studies in the perfused rat hindlimb.Journal of pharmacokinetics and biopharmaceutics · 1995Article
- Physiological pharmacokinetics of solutes in the isolated perfused rat hindlimb: characterization of the physiology with changing perfusate flow, protein content, and temperature using statistical moment analysis.Journal of pharmacokinetics and biopharmaceutics · 1993Article
- Disposition characteristics of protein drugs in the perfused rat kidney.Pharmaceutical research · 1993Article
- Effect of chronic administration of phenobarbital on the hepatobiliary transport of phenol red: assessment by statistical moment analysis.Pharmaceutical research · 1992Article
- Renal tubular handling of p-aminohippurate and epidermal growth factor (EGF) in filtering and nonfiltering perfused rat kidneys.Pharmaceutical research · 1992Article
- Pharmacokinetic analysis of drug absorption from muscle based on a physiological diffusion model: effect of molecular size on absorption.Pharmaceutical research · 1992Article
- Assessment of drug disposition in the perfused rat brain by statistical moment analysis.Pharmaceutical research · 1991Article
- Analysis of arterial-venous blood concentration difference of drugs based on recirculatory theory with fast inverse Laplace transform (FILT).Journal of pharmacokinetics and biopharmaceutics · 1991Article
- Moment analysis of drug disposition in kidney. V: In vivo transepithelial transport of p-aminohippurate in rat kidney.Journal of pharmacokinetics and biopharmaceutics · 1991Article
- Analysis of enterohepatic circulation of cefixime in rat by fast inverse Laplace transform (FILT).Journal of pharmacokinetics and biopharmaceutics · 1990Article
- Statistical moments and disposition parameters in a local perfusion system under mammillary nonequilibrium condition.Journal of pharmacokinetics and biopharmaceutics · 1990Article
- Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).Clinical pharmacokinetics · 1989Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new experimental system is used to determine exact information concerning local drug disposition. Rabbit hind leg is perfused in situ using a single-pass technique, and outflow curves of drugs are analyzed using statistical moment theory. By the introduction of chromatographic concepts and the application of the well-stirred model to the local perfusion system, physiologically and/or physicochemically meaningful parameters are derived from the first three moments. Moreover, in the assessment, drug disposition is divided into elimination and distribution. The elimination process is also evaluated with respect to rate and extent. This system is used to elucidate the disposition characteristics of mitomycin C and its lipophilic derivative nonyloxycarbonyl mitomycin C.
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