Evidence map›Paper›PMID 39388001›Full record

ArticleLasers in medical science2024

Antifungal efficacy of photodynamic therapy on Cryptococcus and Candida species is enhanced by Streptomyces spp. extracts in vitro.

Kunal Ranjan, José Athayde Vasconcelos Morais, Mandeep Dixit, Lourival Carvalho Nunes, Fernando Pacheco Rodrigues, Luís Alexandre Muehlmann, Pratyoosh Shukla, Marcio José Poças-Fonseca

Abstract read
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In one paragraph

Article in Lasers in medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Hydralazine potentiates the antiproliferative effect of photodynamic therapy on Candida albicans and Candida parapsilosis in vitro.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  2. Antifungal and Immunomodulatory Activities of Brazilian SavannahPharmaceuticals (Basel, Switzerland) · 2025
    Article
  3. Effect of Curcumin Pretreatment on the Susceptibility ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kunal RanjanAmity Institute of Biotechnology, Amity University Jharkhand, Ranchi, India.
José Athayde Vasconcelos MoraisGraduation Program in Animal Biology, University of Brasilia, Brasilia, Brazil.
Mandeep DixitDepartment of Botany, Hansraj College, University of Delhi, New Delhi, India.
Lourival Carvalho NunesGraduation Program in Molecular Pathology, University of Brasilia, Brasilia, Brazil.
Fernando Pacheco RodriguesDepartment of Genetics and Morphology, University of Brasilia, Brasilia, Brazil, 70910-900.
Luís Alexandre MuehlmannGraduation Program in Animal Biology, University of Brasilia, Brasilia, Brazil.
Pratyoosh ShuklaEnzyme Technology and Protein Bioinformatics Laboratory, School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi, India.
Marcio José Poças-FonsecaGraduation Program in Molecular Pathology, University of Brasilia, Brasilia, Brazil. mpossas@unb.br.ORCID http://orcid.org/0000-0002-4108-5122

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 0193.001.200/2016Conselho Nacional de Desenvolvimento Científico e Tecnológico 403536/2021/9Fundação de Apoio à Pesquisa do Distrito Federal 00001053/2021-24Fundação de Apoio à Pesquisa do Distrito Federal 00193-00000229/2021-21
6 · The paper itself

Abstract

The research on actinobacteria isolated from traditional medicinal plants is limited. Here, four new Streptomyces isolates (Ha1, Pp1, UzK and UzM) were obtained from the rhizospheres of Helianthus annuus, Pongamia pinnata and Ziziphus mauritiana, frequently utilized in Indian traditional medicine. The Streptomyces isolates aqueous extracts were studied alone against the growth of the Cryptococcus neoformans H99 reference strain, the fluconazole-tolerant T1-5796 and 89-610 strains, three histone deacetylase (HDAC) genes mutant strains, C. gattii NIH198, Candida albicans, C. glabrata, C. parapsilosis and C. tropicalis to determine minimum inhibitory concentration (MIC). Next, the extracts were employed in combination with aluminium-phthalocyanine chloride nanoemulsion-mediated photodynamic therapy to evaluate a possible interaction. We demonstrated that the C. neoformans T1-5796 fluconazole-tolerant strain was more severely inhibited by the Pp1 isolate extract (MIC: 6 mg mL

Indexed as

Antifungal AgentsCandidaMicrobial Sensitivity TestsPhotochemotherapyStreptomycesCryptococcusHumansPhotosensitizing AgentsAntifungal AgentsPhotosensitizing AgentsCandida spp.Cryptococcus spp.Medicine plants rhizospherePhotodynamic therapyStreptomyces spp.

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.