Evidence map›Paper›PMID 39387911›Full record

ArticleClinical oral investigations2024

Cleft lip and palate and periconception COVID-19 infection in five arab countries.

Heba Jafar Sabbagh, Mohammad Zeinalddin, Ola B Al-Batayneh, Taimoor Al Bulushi, Mamdouh A AboulHassan, Mohamed Koraitim, Lateefa Alkharafi, Buthaina Almuqbali, Sultan Musaad Alghamdi, Dania Bahdila and 16 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Factors affecting the use of nasoalveolar molding and feeding appliances among nonsyndromic cleft lip and palate in five countries: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Heba Jafar SabbaghPediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, PO Box 80200, Jeddah, 21589, Saudi Arabia. hsabbagh@kau.edu.sa.ORCID 0000-0002-9788-0379
Mohammad ZeinalddinOmani Craniofacial and Cleft Society, Muscat, Oman.ORCID 0000-0002-0370-8608
Ola B Al-BataynehDepartment of Orthodontics, Pediatric and Community Dentistry, College of Dental Medicine, University of Sharjah, PO Box 27272, Sharjah, United Arab Emirates.ORCID 0000-0003-1670-497X
Taimoor Al BulushiPlastic and Craniofacial Surgery, Khoula Hospital, Muscat, Oman.
Mamdouh A AboulHassanPediatric Plastic Surgery Department, Cairo University, Giza, Egypt.
Mohamed KoraitimMaxillofacial and Plastic Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Lateefa AlkharafiCleft and Craniofacial Unit, Ministry of Health, Kuwait, Kuwait.ORCID 0000-0002-0956-7965
Buthaina AlmuqbaliMinistry of Health, Khoula Hospital, Muscat, Oman.
Sultan Musaad AlghamdiPediatric Dentistry Department, Bisha Dental Centre, Ministry of Health, Bisha, Saudi Arabia.ORCID 0000-0003-3053-5885
Dania BahdilaPediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, PO Box 80200, Jeddah, 21589, Saudi Arabia.
Shaimaa Mohsen RefaheeOral and Maxillofacial Surgery, Faculty of Dentistry, Fayoum University, Fayoum, Egypt.ORCID 0000-0002-7550-1913
Maryam QuritumDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.ORCID 0000-0001-6857-3081
Fatemah Fahad TaqiCleft and Craniofacial Unit, Ministry of Health, Kuwait, Kuwait.ORCID 0000-0003-0674-6615
Bader AlbassamCleft and Craniofacial Unit, Ministry of Health, Kuwait, Kuwait.ORCID 0000-0002-5822-3624
Mariam AyedNeonatal Department, Maternity Hospital, Kuwait, Kuwait.ORCID 0000-0002-8579-000X
Alia EmbaireegNeonatal Department, Maternity Hospital, Kuwait, Kuwait.
Raqiya AlnahdiOman Dental College, Muscat, Oman.
Mona Talal AlSharifDepartment of Dental Public Health, Faculty of Dentistry, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Aziza Johar AljoharResearch Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Fatma Dawood AbdulhameedPediatric Surgery Department, King Salman Medical City, Maternity and Children's Hospital, Madinah, Saudi Arabia.
Najla Sulaiman AlrejayeDepartment of Dentistry, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.ORCID 0000-0002-7113-7827
P S ViswapurnaOman Dental College, Muscat, Oman.
Tamara Al HalasaPreventive Dentistry Department, Faculty of Dentistry, Jordan University of Science & Technology, Irbid, 22110, Jordan.
Maha El TantawiDepartment of Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.ORCID 0000-0003-4989-6584
Osama Adel BasriKing Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.
Rana A AlamoudiPediatric Dentistry Department, Faculty of Dentistry, King Abdulaziz University, PO Box 80200, Jeddah, 21589, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLittle is known about factors associated with the severity of cleft lip with or without cleft palate (CL/P) especially during the COVID-19 pandemic with its dramatic changes.

objectivesThe aim of this multi-national study is to measure the association between CL/P severity, COVID-19 infection, and fear of COVID-19 in five Arab countries.

methodsThis cross-sectional study took place in major governmental hospitals in five Arab countries from November 2020 to April 2023. Participants were infants born with CL/P and their mothers who were in their 1st trimester during the COVID-19 pandemic. Clinical examination was carried out, and CL/P cases were grouped according to phenotype: cleft lip and palate (CLP) versus cleft lip (CL), cleft extension (incomplete versus complete), and site (unilateral versus bilateral) to assess severity. Information on maternal COVID-19 infection and fear of COVID-19 were gathered.

resultsThe study recruited 273 CL/P infants. Maternal COVID-19 infection during one-month pre-gestation and 1st trimester was significantly associated with higher odds of CL/P severity (AOR = 2.707; P = 0.002) than mothers without the COVID-19 infection. Using supplements during pregnancy showed a protective effect (AOR = 0.573; P = 0.065).

conclusionMothers infected with COVID-19 before and during pregnancy had more than twofold higher odds of having an infant with a more severe CL/P phenotype.

Indexed as

Cleft LipCleft PalateCOVID-19Pregnancy Complications, InfectiousAdultCross-Sectional StudiesFemaleHumansInfant, NewbornMaleMiddle EastPregnancySARS-CoV-2Severity of Illness IndexCleft lipCleft palateCOVID-19Orofacial cleftsSaudi ArabiaSeverity

Identifiers

PMID39387911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.