Evidence map›Paper›PMID 39387863›Full record

ArticlePsychopharmacology2025

Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear.

Gabriela V M Oliveira, Paloma M Hernandes, Fábio H Dos Santos, Victor P M N Soares, Luiz Luciano Falconi-Sobrinho, Norberto C Coimbra, Carsten T Wotjak, Rafael Carvalho Almada

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabriela V M OliveiraLaboratory of Neurobiology and Neurobiotechnology, Department of Biological Sciences, School of Sciences, Humanities and Languages of the São Paulo State University (Unesp), Assis, São Paulo, 19806-900, Brazil.
Paloma M HernandesLaboratory of Neurobiology and Neurobiotechnology, Department of Biological Sciences, School of Sciences, Humanities and Languages of the São Paulo State University (Unesp), Assis, São Paulo, 19806-900, Brazil.
Fábio H Dos SantosLaboratory of Neurobiology and Neurobiotechnology, Department of Biological Sciences, School of Sciences, Humanities and Languages of the São Paulo State University (Unesp), Assis, São Paulo, 19806-900, Brazil.
Victor P M N SoaresLaboratory of Neurobiology and Neurobiotechnology, Department of Biological Sciences, School of Sciences, Humanities and Languages of the São Paulo State University (Unesp), Assis, São Paulo, 19806-900, Brazil.
Luiz Luciano Falconi-SobrinhoLaboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Ribeirão Preto, São Paulo, Brazil.
Norberto C CoimbraLaboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Ribeirão Preto, São Paulo, Brazil.
Carsten T WotjakCentral Nervous System Diseases Research, Boehringer Ingelheim Pharmaceuticals Die Gesellschaft mit Beschränkter Haftung & Compagnie Kommanditgesellschaft, Biberach Riss, Germany.
Rafael Carvalho AlmadaLaboratory of Neurobiology and Neurobiotechnology, Department of Biological Sciences, School of Sciences, Humanities and Languages of the São Paulo State University (Unesp), Assis, São Paulo, 19806-900, Brazil. rc.almada@unesp.br.ORCID http://orcid.org/0000-0003-3215-7435

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 142030/2020-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.498215/2020-00Fundação de Amparo à Pesquisa do Estado de São Paulo 019/15757-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/03898-1 and 2019/01713-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/05255-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/02724-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/15050-7 and 2021/14073-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/06557-3German-Israeli Foundation for Scientific Research and Development I-1442-421. 13/2017
6 · The paper itself

Abstract

rationaleDespite the existing anatomical and physiological evidence pointing to the involvement of orexinergic projections from the lateral hypothalamus (LH) in regulating fear-related responses, little is known regarding the contribution of the orexin system in the prelimbic cortex (PL) on contextual fear.

objectivesWe investigated the role of orexin-A (Orx

methodsNeural tract tracing of the LH-PL pathway and Orx

resultsNeural tract tracing deposits in the LH showed some perikarya, mainly axons and terminal buttons in the PL, suggesting LH-PL reciprocate pathways. Furthermore, we showed a profuse network comprised of Orx

conclusionIn summary, these data confirmed an anatomical link between LH and PL, established the presence of Orx

Indexed as

Conditioning, PsychologicalFearOrexin ReceptorsOrexinsPrefrontal CortexAnimalsBenzoxazolesConditioning, ClassicalDose-Response Relationship, DrugHypothalamic Area, LateralMaleMiceMice, Inbred C57BLNaphthyridinesOrexin Receptor AntagonistsUrea1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl ureaBenzoxazolesNaphthyridinesOrexin Receptor AntagonistsOrexin ReceptorsOrexinsUreaContextual fear conditioningMedial prefrontal cortexOrexin-AOrexin type 1 receptorPrelimbic cortex

Identifiers

PMID39387863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.