Evidence map›Paper›PMID 39387586›Full record

ArticlemBio2024

Lipophilic bisphosphonates reduced cyst burden and ameliorated hyperactivity of mice chronically infected with

Melissa A Sleda, Zaid F Pitafi, WenZhan Song, Eric Oldfield, Silvia N J Moreno

Abstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Legacy 4(1ACS infectious diseases · 2026
    Article
  2. Article
  3. Article
  4. First In Silico Study of TwoInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melissa A SledaCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-8987-2937
Zaid F PitafiSchool of Electrical and Computer Engineering, University of Georgia, Athens, Georgia, USA.
WenZhan SongSchool of Electrical and Computer Engineering, University of Georgia, Athens, Georgia, USA.
Eric OldfieldDepartment of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois, USA.
Silvia N J MorenoCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID 0000-0002-2041-6295

Funding

Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
Validation of the ubiquinone synthesis pathway of Toxoplasma gondii as a novel drug targetR01AI169846 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2022 to 2025
$2.1M
SCH: Contactless and Engagement-free Sleep Apnea Monitoring and CharacterizationR01HL172291 · NHLBI · UNIVERSITY OF GEORGIA · PI Yuan Ke, BRADLEY GEORGE PHILLIPS · 2023 to 2026
$1.2M
Anti-Toxoplasma isoprenoid pathway inhibitors and the host immune responseR21AI147661 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2020 to 2021
$415k
Harriet A. Harlin ProfessorshipHHS | National Institutes of Health (NIH) R01AI169846HHS | National Institutes of Health (NIH) R01HL17229HHS | National Institutes of Health (NIH) R21AI147661HHS | National Institutes of Health (NIH) T32AI060546National Science Foundation (NSF) 1940864National Science Foundation (NSF) 2019311National Science Foundation (NSF) 2312974National Science Foundation (NSF) 2324389NHLBI NIH HHS R01 HL172291NIAID NIH HHS R01 AI169846NIAID NIH HHS R21 AI147661NIAID NIH HHS T32 AI060546University of Illinois FoundationU.S. Department of Defense (DOD) EE0009026U.S. Department of Defense (DOD) FA8571-21-C-0020
6 · The paper itself

Abstract

The current treatments for toxoplasmosis are only active against fast-growing tachyzoites, present in acute infections, with little effect on slow-growing bradyzoites within tissue cysts, present in latent chronic infections. The mitochondrion of

Indexed as

DiphosphonatesToxoplasmaAnimalsAntiprotozoal AgentsBrainChronic DiseaseDisease Models, AnimalFemaleMiceToxoplasmosisToxoplasmosis, AnimalUbiquinoneAntiprotozoal AgentsDiphosphonatesUbiquinonebisphosphonatebradyzoitehyperactivityToxoplasma gondii

Identifiers

PMID39387586
PMCPMC11558998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.