Evidence map›Paper›PMID 39387198›Full record

ArticleThe British journal of nutrition2024

Investigating thyroid function and iodine status in adolescents with and without paediatric major depressive disorder.

Ester Osuna, Jeannine Baumgartner, Andreas Walther, Sophie Emery, Mona Albermann, Noemi Baumgartner, Klaus Schmeck, Susanne Walitza, Michael Strumberger, Martin Hersberger and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ester OsunaLaboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0001-7706-6102
Jeannine BaumgartnerDepartment of Nutritional Sciences, King's College London, London, UK.
Andreas WaltherDepartment of Clinical Psychology and Psychotherapy, University of Zurich, Zurich, Switzerland.
Sophie EmeryDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Mona AlbermannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Noemi BaumgartnerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Klaus SchmeckDepartment of Clinical Research, Medical Faculty, University of Basel, Basel, Switzerland.
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Michael StrumbergerResearch Department of Child and Adolescent Psychiatry, Psychiatric University Hospitals Basel, University of Basel, Basel, Switzerland.
Martin HersbergerDivision of Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Michael B ZimmermannLaboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zürich, Zürich, Switzerland.
Isabelle HäberlingDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Gregor BergerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
Isabelle Herter-AeberliLaboratory of Nutrition and Metabolic Epigenetics, Institute of Food, Nutrition and Health, ETH Zürich, Zürich8092, Switzerland.ORCID https://orcid.org/0000-0003-0134-6217
Omega-3 study team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression has been associated with subclinical hypothyroidism and altered hypothalamic-pituitary-thyroid axis functioning. Adequate iodine nutrition is essential for healthy thyroid functioning. We therefore determined associations of iodine and thyroid status with paediatric major depressive disorder (pMDD) among Swiss adolescents and explored whether associations are sex-specific and mediated by stress. We conducted a matched case-control study in 95 adolescents with diagnosed pMDD and 95 healthy controls. We assessed depression severity using the Children's Depression Rating Scale-Revised and stress using the perceived stress scale (PSS) and measuring hair cortisol levels. We determined iodine status by measuring urinary iodine concentrations (UIC) and thyroid status by thyroid-stimulating hormone (TSH) and free thyroxine (FT4) in serum. Median (IQR) UIC did not differ between cases (121 (87, 174) µg/l) and controls (114 (66, 183) μg/l,

Indexed as

HairHydrocortisoneIodineMajor Depressive DisorderNutritional StatusThyroid GlandThyrotropinThyroxineAdolescentCase-Control StudiesChildFemaleHumansHypothyroidismMaleStress, PsychologicalHydrocortisoneIodineThyrotropinThyroxineAdolescentsHypothyroxinaemiaIodinePaediatric Major Depressive Disorder

Identifiers

PMID39387198
PMCPMC11557290

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.