ArticleArteriosclerosis, thrombosis, and vascular biology2024
ASGR1 Deficiency Inhibits Atherosclerosis in Western Diet-Fed
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13 citing papers in PubMed.
- Dyslipidaemia and hepatic steatosis: mechanisms and implications for lipid-lowering therapy.Nature reviews. Cardiology · 2026Review
- In vivo base editing of Asgr1 reduces blood lipids in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Targeting cytokine-like protein FAM3D alleviates atherosclerosis.Cell reports. Medicine · 2026Article
- The asialoglycoprotein receptor 1 (ASGR1): emerging new roles in health and disease.Biomarker research · 2026Review
- Elevated ASGR1 as a Potential Diagnostic Biomarker for Coronary Artery Disease and Predictor of Adverse Outcomes in Hypertensive Patients.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Fisetin-loaded nanoparticles as a novel approach for cholesterol regulation in hypercholesterolemia: targeting the ASGR1-mediated mTORC1/AMPK pathway.Journal of nanobiotechnology · 2026Article
- Serum soluble ASGR1 concentration is elevated in patients with metabolic dysfunction-associated steatotic liver disease and is associated with adiponectin.BMJ open diabetes research & care · 2026Article
- Unveiling the PGAM5-ANGPTL3 Axis: Implications for Atherosclerosis Progression and Therapy.JACC. Basic to translational science · 2025Article
- Therapeutic effects and mechanisms of Fufang Longdan mixture on metabolic syndrome with psoriasis via miR-29a-5p/IGF-1R axis.Frontiers in pharmacology · 2025Article
- Asialoglycoprotein receptor 1: a multifaceted receptor in the liver and cardiovascular system.Frontiers in medicine · 2025Review
- Serum Soluble Asialoglycoprotein Receptor 1: A Potential Predictor Marker Linked to Type 2 Diabetes Mellitus, Demonstrating Positive Correlation With High Sensitive C-Reactive Protein.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Article
- Adding a New Piece to the ASGR1 Puzzle: ANGPTL3.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
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Authors and funding
16 authors.
Yuyan Zhang *State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0009-0004-8318-8172
Xinhai Jiang *State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0000-0003-0585-215X
Weizhi Wang *State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0000-0001-7233-3697
Lijuan LeiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0009-0001-0460-4544
Ren ShengState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0000-0002-3164-2722
Shunwang LiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0009-0000-4436-439X
Jinque LuoState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0000-0002-2744-2867
Huan LiuDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (J.L., H.L., Z.-G.J.).ORCID 0000-0002-2676-6982
Jing ZhangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0000-0003-2299-1979
Xiaowan HanState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0000-0002-8945-8530
Yining LiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0009-0009-3813-5510
Yuhao ZhangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0009-0005-8998-0889
Chenyin WangState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0000-0002-4963-777X
Shuyi SiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0000-0003-4422-6848
Zheng-Gen JinDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY (J.L., H.L., Z.-G.J.).ORCID 0000-0002-8367-5526
Yanni XuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC (National Health Commission) Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China (Yuyan Zhang, X.J., W.W., L.L., R.S., S.L., J.L., J.Z., X.H., Y.L., Yuhao Zhang, C.W., S.S., Y.X.).ORCID 0000-0003-1539-0606
Funding
SIRT6 and vascular endothelial homeostasisR01HL130167 · NHLBI · UNIVERSITY OF ROCHESTER · PI JIN, ZHENG-GEN · 2017 to 2025
$4.2MEpigenetic regulation of vascular endothelial genes and laminar flow atheroprotectionR01HL141171 · NHLBI · UNIVERSITY OF ROCHESTER · PI JIN, ZHENG-GEN · 2019 to 2022
$1.9MNHLBI NIH HHS R01 HL130167NHLBI NIH HHS R01 HL141171
Abstract
backgroundAtherosclerosis is the most common cause of cardiovascular diseases. Clinical studies indicate that loss-of-function ASGR1 (asialoglycoprotein receptor 1) is significantly associated with lower plasma cholesterol levels and reduces cardiovascular disease risk. However, the effect of ASGR1 on atherosclerosis remains incompletely understood; whether inhibition of ASGR1 causes liver injury remains controversial. Here, we comprehensively investigated the effects and the underlying molecular mechanisms of ASGR1 deficiency and overexpression on atherosclerosis and liver injury in mice.
methodsWe engineered
resultsAfter being fed a Western diet for 12 weeks,
conclusionsInhibition of ASGR1 inhibits atherosclerosis in Western diet-fed
Indexed as
Asialoglycoprotein ReceptorAtherosclerosisCholesterolDiet, WesternDisease Models, AnimalLiverMice, Inbred C57BLMice, Knockout, ApoEAnimalsAortaAortic DiseasesApolipoproteins EATP Binding Cassette Transporter, Subfamily G, Member 5MacrophagesMaleMiceApoe protein, mouseApolipoproteins EAsialoglycoprotein ReceptorATP Binding Cassette Transporter, Subfamily G, Member 5Cholesterolasialoglycoprotein receptor 1atherosclerosiscardiovascular diseasescholesterol effluxlipoprotein metabolism
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