Evidence map›Paper›PMID 39387105›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Cognition in (pre)symptomatic Dutch-type hereditary and sporadic cerebral amyloid angiopathy.

Rosemarie van Dort, Kanishk Kaushik, Ingeborg Rasing, Reinier G J van der Zwet, Manon R Schipper, Jeroen van der Grond, Sanneke van Rooden, Erik W van Zwet, Gisela M Terwindt, Huub A M Middelkoop and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Cognitive decline in Dutch-type hereditary and sporadic cerebral amyloid angiopathy: a 5-year follow-up study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Review
  3. Article
  4. Clinical Management of Cerebral Amyloid Angiopathy.Journal of clinical medicine · 2025
    Review
  5. Review
  6. Cognition in (pre)symptomatic Dutch-type hereditary and sporadic cerebral amyloid angiopathy.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rosemarie van DortDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-7777-3189
Kanishk KaushikDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Ingeborg RasingDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Reinier G J van der ZwetDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Manon R SchipperDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Jeroen van der GrondDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Sanneke van RoodenDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Erik W van ZwetDepartment of Biostatistics, Leiden University Medical Center, Leiden, The Netherlands.
Gisela M TerwindtDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Huub A M MiddelkoopDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Ellen P HartDepartment of Finance, Leiden University Medical Center, Leiden, The Netherlands.
Matthias J P van OschDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Marianne A A van WalderveenDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
Marieke J H WermerDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.

Funding

Dutch CAA foundationTRACK D-CAA consortiumVereniging HCHWA-D
6 · The paper itself

Abstract

introductionCerebral amyloid angiopathy (CAA) is a main cause of cognitive dysfunction in the elderly. We investigated specific cognitive profiles, cognitive function in the stage before intracerebral hemorrhage (ICH), and the association between magnetic resonance imaging (MRI) based cerebral small vessel disease (cSVD) burden in CAA because data on these topics are limited.

methodsWe included Dutch-type hereditary CAA (D-CAA) mutation carriers with and without ICH, patients with sporadic CAA (sCAA), and age-matched controls. Cognition was measured with a standardized test battery. Linear regression was performed to assess the association between MRI-cSVD burden and cognition.

resultsD-CAA ICH- mutation carriers exhibited poorer global cognition and executive function compared to age-matched controls. Patients with sCAA performed worse across all cognitive domains compared to D-CAA ICH+ mutation carriers and age-matched controls. MRI-cSVD burden is associated with decreased processing speed. DISCUSSION: CAA is associated with dysfunction in multiple cognitive domains, even before ICH, with increased MRI-cSVD burden being associated with slower processing speed. HIGHLIGHTS: Cognitive dysfunction is present in early disease stages of cerebral amyloid angiopathy (CAA) before the occurrence of symptomatic intracerebral hemorrhage (sICH). Presymptomatic Dutch-type CAA (D-CAA) mutation carriers show worse cognition than age-matched controls. More early awareness of cognitive dysfunction in CAA before first sICH is needed. Increased cerebral small vessel disease CAA-burden on magnetic resonance imaging is linked to a decrease in processing speed.

Indexed as

Cerebral Amyloid AngiopathyMagnetic Resonance ImagingNeuropsychological TestsAgedCerebral Amyloid Angiopathy, FamilialCerebral HemorrhageCognitionCognitive DysfunctionExecutive FunctionFemaleHumansMaleMiddle AgedMutationNetherlandscerebral amyloid angiopathycerebral small vessel disease burdencognitive dysfunctionDutch‐type hereditary cerebral amyloid angiopathyhereditary cerebral amyloid angiopathyintracerebral hemorrhagemagnetic resonance imagingpresymptomatic mutation carriers

Identifiers

PMID39387105
PMCPMC11567850

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.