Evidence map›Paper›PMID 39386832›Full record

ArticleHeliyon2024

Novel quinoline-4-carboxamide derivatives potentiates apoptosis by targeting PDK1 to overcome chemo-resistance in colorectal cancer: Theoretical and experimental results.

Shalini V, Priyadarshini A N, Harsha Kachigere B, Vinay Kumar D C, Darshini Gowda, Chethan B S, Sudhanva M Srinivasa, Shobith Rangappa, Kanchugarakoppal S Rangappa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shalini VDepartment of Studies in Chemistry, Manasagangotri, University of Mysore, Mysuru, 570 006, Karnataka, India.
Priyadarshini A NAdichunchanagiri Institute for Molecular Medicine, Adichunchanagiri Institute of Medical Sciences, Adichunchanagiri University, BG Nagara, 571 448, Karnataka, India.
Harsha Kachigere BDepartment of Chemistry, Mysore University School of Engineering, Manasagangotri, University of Mysore, Mysuru, 570 006, Karnataka, India.
Vinay Kumar D CDepartment of Studies in Physics, University of Mysore, Manasagangotri, Mysuru, 570 006, Karnataka, India.
Darshini GowdaDepartment of Studies in Chemistry, Manasagangotri, University of Mysore, Mysuru, 570 006, Karnataka, India.
Chethan B SDepartment of Studies in Physics, University of Mysore, Manasagangotri, Mysuru, 570 006, Karnataka, India.
Sudhanva M SrinivasaAdichunchanagiri Institute for Molecular Medicine, Adichunchanagiri Institute of Medical Sciences, Adichunchanagiri University, BG Nagara, 571 448, Karnataka, India.
Shobith RangappaAdichunchanagiri Institute for Molecular Medicine, Adichunchanagiri Institute of Medical Sciences, Adichunchanagiri University, BG Nagara, 571 448, Karnataka, India.
Kanchugarakoppal S RangappaDepartment of Studies in Chemistry, Manasagangotri, University of Mysore, Mysuru, 570 006, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of novel N,2-diphenyl-6-(aryl/heteroaryl)quinoline-4-carboxamide derivatives were designed and synthesized using the Suzuki coupling reaction and evaluated them for their anticancer activity. These compounds were screened for anti-colon cancer activity through

Indexed as

ADMETChemo-resistanceColorectal cancerDFTMolecular dockingMolecular dynamicsPDK1Quinoline-4-carboxamide derivatives

Identifiers

PMID39386832
PMCPMC11462461

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.