Evidence map›Paper›PMID 39386713›Full record

ArticlebioRxiv : the preprint server for biology2024

Complement therapeutic Factor H-IgG proteins as pre-exposure prophylaxes against Lyme borreliae infections.

Connor W McKaig, Jill Malfetano, Y Tran, Xiuli Yang, Utpal Pal, Keith Wycoff, Yi-Pin Lin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Connor W McKaigDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
Jill MalfetanoDivision of Infectious Diseases, Wadsworth Center, NYSDOH, Albany, NY, USA.
Y TranPlanet Biotechnology, Inc., Hayward, CA, USA.
Xiuli YangDepartment of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, United States.
Utpal PalDepartment of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, United States.
Keith WycoffPlanet Biotechnology, Inc., Hayward, CA, USA.
Yi-Pin LinDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.ORCID 0000-0002-5240-2031

Funding

FH-Fc as a Pre-Exposure Prophylactic for Tickborne DiseaseR44AI152954 · NIAID · PLANET BIOTECHNOLOGY, INC. · PI LIN, YI-PIN, WYCOFF, KEITH · 2022 to 2023
$2.0M
FH-Fc as a Pre-Exposure Prophylactic for Tickborne DiseaseR41AI152954 · NIAID · PLANET BIOTECHNOLOGY, INC. · PI WYCOFF, KEITH · 2020 to 2021
$445k
Identification of the mechanism of protection against a B. burgdorferi protein CspZ for the prevention of Lyme diseaseR21AI144891 · NIAID · WADSWORTH CENTER · PI BOTTAZZI, MARIA ELENA, LIN, YI-PIN · 2020 to 2021
$441k
NIAID NIH HHS R21 AI144891NIAID NIH HHS R41 AI152954NIAID NIH HHS R44 AI152954
6 · The paper itself

Abstract

Lyme disease (LD) is the most common vector-borne disease in the northern hemisphere and is caused by the bacteria

Indexed as

BorreliacomplementFH-FcLyme diseasePre-exposure prophylaxis

Identifiers

PMID39386713
PMCPMC11463399

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.