Evidence map›Paper›PMID 39386684›Full record

ArticlebioRxiv : the preprint server for biology2024

Intestinal Epithelial PTPN2 Limits Pathobiont Colonization by Immune-Directed Antimicrobial Responses.

Pritha Chatterjee, Marianne R Spalinger, Charly Acevedo, Casey M Gries, Salomon M Manz, Vinicius Canale, Alina N Santos, Ali Shawki, Anica Sayoc-Becerra, Hillmin Lei and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Pritha ChatterjeeDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Marianne R SpalingerDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Charly AcevedoDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Casey M GriesDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Salomon M ManzDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Vinicius CanaleDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Alina N SantosDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Ali ShawkiDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Anica Sayoc-BecerraDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Hillmin LeiDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Meli'sa S CrawfordDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.
Lars EckmannDivision of Gastroenterology, University of California, San Diego, La Jolla, California.
James BornemanDepartment of Microbiology and Plant Pathology, University of California, Riverside, Riverside, California.
Declan F McColeDivision of Biomedical Sciences, University of California, Riverside, Riverside, California.ORCID 0000-0002-6286-0802

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LARS ECKMANN, Bernd G. Schnabl · 2019 to 2026
$10.8M
A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATIONR01DK091281 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Declan McCole · 2012 to 2026
$5.5M
Tyrosine Phosphatase Regulation of Mucosal Macrophage-Epithelial Cell Cross-talkR01AI153314 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MCCOLE, DECLAN · 2020 to 2024
$2.5M
Inflammatory Bowel Disease Susceptibility Gene Regulation of AnemiaR21AI152017 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MCCOLE, DECLAN · 2021 to 2022
$428k
NIAID NIH HHS R01 AI153314NIAID NIH HHS R21 AI152017NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK091281
6 · The paper itself

Abstract

Background and Aims: Loss of activity of the inflammatory bowel disease (IBD) susceptibility gene, protein tyrosine phosphatase non-receptor type 2 ( Methods: Tamoxifen-inducible, intestinal epithelial cell-specific Results: Conclusion: Our findings highlight that intestinal epithelial PTPN2 is crucial for mucosal immunity and gut homeostasis by promoting anti-bacterial defense mechanisms involving coordinated epithelial-immune responses to restrict pathobiont colonization.

Identifiers

PMID39386684
PMCPMC11463449

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.