Evidence map›Paper›PMID 39386679›Full record

ArticlebioRxiv : the preprint server for biology2025

Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP Signaling.

Rachel Nakagawa, Andrew Beardsley, Sophia Durney, Mary-Kate Hayward, Vishvak Subramanyam, Nathaniel P Meyer, Harrison Wismer, Hani Goodarzi, Valerie M Weaver, Daniel Van de Mark and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rachel NakagawaDepartment of Cell & Tissue Biology, University of California, San Francisco, CA, USA.ORCID 0000-0001-7626-8757
Andrew BeardsleyDepartment of Cell & Tissue Biology, University of California, San Francisco, CA, USA.
Sophia DurneyDepartment of Cell & Tissue Biology, University of California, San Francisco, CA, USA.ORCID 0000-0003-4217-5741
Mary-Kate HaywardDepartment of Surgery and Center for Bioengineering and Tissue Regeneration, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-7482-5046
Vishvak SubramanyamDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.ORCID 0000-0002-6144-8322
Nathaniel P MeyerDepartment of Cell & Tissue Biology, University of California, San Francisco, CA, USA.ORCID 0000-0002-8327-8563
Harrison WismerBiological Imaging Development CoLab, UCSF, San Francisco, CA, USA.
Hani GoodarziDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.ORCID 0000-0002-9648-8949
Valerie M WeaverDepartment of Surgery and Center for Bioengineering and Tissue Regeneration, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-4786-6752
Daniel Van de MarkDepartment of Cell & Tissue Biology, University of California, San Francisco, CA, USA.
Andrei GogaDepartment of Cell & Tissue Biology, University of California, San Francisco, CA, USA.ORCID 0000-0001-9127-0986

Funding

Development of CapCell Scope for Metabolic Imaging of Tissue Heterogeneity and Therapy ResponseR01EB028148 · NIBIB · DUKE UNIVERSITY · PI ANDREI GOGA, Nirmala Ramanujam · 2019 to 2026
$4.0M
In Vivo Metabolic Catastrophe Is Induced By Acute Oncogene Inhibition (PQ #22)R01CA170447 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2012 to 2015
$2.4M
Targeting the MYC Oncogene with CDK InhibitorsR01CA136717 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2010 to 2014
$1.8M
Molecular Pathology of CancerT32CA177555 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASTIAN, BORIS C., OAKES, SCOTT A. · 2013 to 2017
$1.1M
Investigating the function of subclonal cooperation in breast cancer progressionF31CA265248 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAKAGAWA, RACHEL MARIE · 2021 to 2024
$114k
NCI NIH HHS F31 CA265248NCI NIH HHS R01 CA136717NCI NIH HHS R01 CA170447NCI NIH HHS T32 CA177555NIBIB NIH HHS R01 EB028148
6 · The paper itself

Abstract

Non-small cell lung cancers (NSCLC) harboring common mutations in EGFR and KRAS characteristically respond transiently to targeted therapies against those mutations, but invariably, tumors recur and progress. Resistance often emerges through mutations in the therapeutic target or activation of alternative signaling pathways. Mechanisms of acute tumor cell resistance to initial EGFR (EGFRi) or KRAS

Indexed as

afatinibARS-1620BRAFV600EEGFRKRASG12CmonolayerNon-small cell lung cancer (NSCLC)osimertinibspheroidvemurafenib

Identifiers

PMID39386679
PMCPMC11463411

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.