Evidence map›Paper›PMID 39386617›Full record

ArticlebioRxiv : the preprint server for biology2024

MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis.

Lucky Sarkar, GuanQun Liu, Dhiraj Acharya, Junji Zhu, Zuberwasim Sayyad, Michaela U Gack

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lucky SarkarFlorida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL 34987, USA.
GuanQun LiuFlorida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL 34987, USA.
Dhiraj AcharyaFlorida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL 34987, USA.
Junji ZhuFlorida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL 34987, USA.
Zuberwasim SayyadFlorida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL 34987, USA.
Michaela U GackFlorida Research and Innovation Center, Cleveland Clinic, Port St. Lucie, FL 34987, USA.

Funding

Regulation of Host Innate Immunity Against Viral InfectionR37AI087846 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI Michaela Ulrike Gack · 2021 to 2026
$2.8M
NIAID NIH HHS R37 AI087846
6 · The paper itself

Abstract

The posttranslational modification (PTM) of innate immune sensor proteins by ubiquitin or ubiquitin-like proteins is crucial for regulating antiviral host responses. The cytoplasmic dsRNA receptor melanoma differentiation-associated protein 5 (MDA5) undergoes several PTMs including ISGylation within its first caspase activation and recruitment domain (CARD), which promotes MDA5 signaling. However, the relevance of MDA5 ISGylation for antiviral immunity in an infected organism has been elusive. Here, we generated knock-in mice (

Indexed as

EMCVHERC5HERC6Innate immunityInterferonISG15ISGylationMDA5

Identifiers

PMID39386617
PMCPMC11463472

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.