Evidence map›Paper›PMID 39386579›Full record

ArticlebioRxiv : the preprint server for biology2024

Impaired excitability of fast-spiking neurons in a novel mouse model of

Eric R Wengert, Melody A Cheng, Sophie R Liebergall, Kelly H Markwalter, Yerahm Hong, Leroy Arias, Eric D Marsh, Xiaohong Zhang, Ala Somarowthu, Ethan M Goldberg

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Eric R WengertDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, U.S.A.
Melody A ChengSchool of Arts and Sciences, The University of Pennsylvania, Philadelphia, PA, U.S.A.
Sophie R LiebergallThe Medical Scientist Training Program, The University of Pennsylvania Perelman School of Medicine, Philadelphia, U.S.A.
Kelly H MarkwalterDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, U.S.A.
Yerahm HongSchool of Engineering and Applied Sciences, The University of Pennsylvania, Philadelphia, PA, U.S.A.
Leroy AriasSchool of Arts and Sciences, The University of Pennsylvania, Philadelphia, PA, U.S.A.
Eric D MarshDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, U.S.A.
Xiaohong ZhangDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, U.S.A.
Ala SomarowthuDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, U.S.A.
Ethan M GoldbergDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, U.S.A.

Funding

The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Michael Byrne Robinson · 2021 to 2026
$9.2M
Mechanistically-oriented therapy for a progressive myoclonus epilepsyR01NS122887 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ETHAN M GOLDBERG · 2022 to 2026
$2.5M
Mechanisms of cellular, synaptic and circuit dysfunction in Kcnc1-related epileptic encephalopathyF32NS126234 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI WENGERT, ERIC RYAN · 2022 to 2024
$218k
Cellular and circuit function of Ndnf-expressing interneurons in a mouse model of a neurodevelopmental disorderF31NS132519 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LIEBERGALL, SOPHIE ROSE · 2023 to 2025
$124k
NICHD NIH HHS P50 HD105354NINDS NIH HHS F31 NS132519NINDS NIH HHS F32 NS126234NINDS NIH HHS R01 NS122887
6 · The paper itself

Abstract

The recurrent pathogenic variant

Identifiers

PMID39386579
PMCPMC11463657

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.