ArticlebioRxiv : the preprint server for biology2025
Interleukin 6 drives durable T cell-mediated immunity to pancreatic cancer.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background & Aims: Tumor immune resistance is recognized as a contributor to low survivorship in pancreatic ductal adenocarcinoma (PDAC). The inflammatory cytokine interleukin-6 (IL-6) promotes polarization of CD4 T cell populations away from immune tolerance, induces differentiation of cytotoxic CD8 T cells, and drives expansion and anti-tumor activity in chimeric antigen receptor (CAR) T cell therapies. This work aims to test whether IL-6 could stimulate an anti-tumor response in PDAC. Methods: We overexpressed IL-6 in multiple Kras Results: Improved survival occurred in all instances of OT-PDAC Conclusions: Locally high IL-6 concentrations potently enhance the T cell-mediated anti-tumor response to PDAC.
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