Evidence map›Paper›PMID 39386555›Full record

ArticlebioRxiv : the preprint server for biology2024

TNFSF13 insufficiency disrupts human colonic epithelial cell-mediated B cell differentiation.

Xianghui Ma, Noor Dawany, Ayano Kondo, Kelly Maurer, Tatiana Karakasheva, Rawan Shraim, Patrick A Williams, Louis R Parham, Lauren A Simon, Charles H Danan and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Xianghui MaDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Noor DawanyDepartment of Biomedical and Health Informatics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Ayano KondoDepartment of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, Philadelphia, PA, 19104, USA.
Kelly MaurerDivision of Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Tatiana KarakashevaDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Rawan ShraimDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Patrick A WilliamsDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Louis R ParhamDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Lauren A SimonDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Charles H DananDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Maire A ConradDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
David A PiccoliDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Marcella DevotoInstitute for Research in Genetics and Biomedicine, CNR, Cagliari, Italy, and Department of Translational and Precision Medicine, University Sapienza, Rome, Italy.
Kathleen E SullivanDivision of Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Klaus H KaestnerDepartment of Genetics and Center for Molecular Studies in Digestive and Liver Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, Philadelphia, PA, 19104, USA.
Judith R KelsenDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.
Kathryn E HamiltonDivision of Gastroenterology, Hepatology, and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; Philadelphia, PA, 19104, USA.

Funding

TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5M
Integration of genomics and transcriptomics to investigate biological pathways in very early onset IBDR01DK127044 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI KELSEN, JUDITH RACHEL · 2021 to 2025
$3.4M
Defining post-transcriptional regulons in intestinal epithelial regenerationR01DK124369 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI HAMILTON, KATHRYN ELIZABETH · 2020 to 2024
$2.6M
NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R01 DK124369NIDDK NIH HHS R01 DK127044
6 · The paper itself

Abstract

Cytokines mediating epithelial and immune cell interactions modulate mucosal healing- a process that goes awry with chronic inflammation as in inflammatory bowel disease. TNFSF13 is a cytokine important for B cell maturation and function, but roles for epithelial TNFSF13 and putative contribution to inflammatory bowel disease are poorly understood. We evaluated functional consequences of a novel monoallelic

Identifiers

PMID39386555
PMCPMC11463615

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.