Evidence map›Paper›PMID 39386536›Full record

ArticlebioRxiv : the preprint server for biology2025

B cell αv integrin regulates tissue specialization and clonal expansion of lung germinal center and memory B cells after viral infection.

Andrea Montiel-Armendariz, Kelsey Roe, Jonathan Lagos-Orellana, Laura Veronica Martinez-Castro, Matthew J Dufort, Oliver Harrison, Adam Lacy-Hulbert, Mridu Acharya

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Andrea Montiel-ArmendarizCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.
Kelsey RoeCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.
Jonathan Lagos-OrellanaCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.
Laura Veronica Martinez-CastroCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.
Matthew J DufortCenter for Systems Immunology, Benaroya Research Institute, Seattle, WA.
Oliver HarrisonCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA.
Adam Lacy-HulbertCenter for Systems Immunology, Benaroya Research Institute, Seattle, WA.
Mridu AcharyaCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA.

Funding

Manipulating alpha(v) integrins on B cells to promote lung-resident B cell responsesR01AI151167 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI Mridu Acharya · 2020 to 2026
$3.3M
NIAID NIH HHS R01 AI151167
6 · The paper itself

Abstract

Lung-resident B cells are increasingly recognized as key contributors to protective immunity against respiratory viruses, yet the mechanisms that govern their generation and specialization remain poorly understood. Here, we identify B cell-intrinsic αv integrin as a critical negative regulator of germinal center (GC) dynamics and memory B cell formation in the lung following influenza A virus (IAV) infection. Using B cell-specific αv knockout mice, we show that loss of B cell αv integrin leads to persistent GC activity within the inducible bronchus-associated lymphoid tissue and expansion of lung-resident memory B cells, including IgA

Identifiers

PMID39386536
PMCPMC11463618

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.