Evidence map›Paper›PMID 39386513›Full record

ArticlebioRxiv : the preprint server for biology2024

Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantification.

Rachel J Harding, Yuanyun Xie, Nicholas S Caron, Hailey Findlay-Black, Caroline Lyu, Nalini Potluri, Renu Chandrasekaran, Michael R Hayden, Blair R Leavitt, Douglas R Langbehn and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Rachel J HardingLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.ORCID 0000-0002-1134-391X
Yuanyun XieBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, 32827, USA.
Nicholas S CaronCentre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, BC V5Z 4H4 Canada.
Hailey Findlay-BlackCentre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, BC V5Z 4H4 Canada.
Caroline LyuStructural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada.
Nalini PotluriBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, 32827, USA.
Renu ChandrasekaranLeslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
Michael R HaydenCentre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, BC V5Z 4H4 Canada.ORCID 0000-0001-5159-1419
Blair R LeavittCentre for Molecular Medicine and Therapeutics, The University of British Columbia, Vancouver, BC V5Z 4H4 Canada.
Douglas R LangbehnDepartment of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Amber L SouthwellBurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL, 32827, USA.

Funding

Delineating factors that modulate huntingtin secretion and its role in Huntington disease pathogenesisR01NS116099 · NINDS · UNIVERSITY OF CENTRAL FLORIDA · PI SOUTHWELL, AMBER L · 2020 to 2024
$2.1M
NINDS NIH HHS R01 NS116099Wellcome Trust
6 · The paper itself

Abstract

Huntington disease (HD) is a progressive and devastating neurodegenerative disease caused by expansion of a glutamine-coding CAG tract in the huntingtin (

Indexed as

BiomarkersHuntingtin DetectionHuntingtin Lowering TherapiesHuntington’s Disease

Identifiers

PMID39386513
PMCPMC11463412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.