Evidence map›Paper›PMID 39386496›Full record

ArticlebioRxiv : the preprint server for biology2024

BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequences.

Sanad M El-Khatib, Arya R Vagadia, Anh C D Le, Ding Quan Ng, Janet E Baulch, Mingyu Du, Zhiqun Tan, Xiangmin Xu, Alexandre Chan, Munjal M Acharya

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sanad M El-Khatib
Arya R Vagadia
Anh C D Le
Ding Quan Ng
Janet E Baulch
Mingyu Du
Zhiqun Tan
Xiangmin Xu
Alexandre Chan
Munjal M Acharya

Funding

Glial immune signaling in radiation-induced brain injuryR01CA251110 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI ACHARYA, MUNJAL M · 2021 to 2025
$2.3M
Neurotrophic strategy to mitigate chemotherapy-related brain injuryR01CA276212 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Munjal M Acharya, Alexandre Chan · 2023 to 2026
$1.9M
NCI NIH HHS R01 CA251110NCI NIH HHS R01 CA276212
6 · The paper itself

Abstract

Cranial radiation therapy (RT) for brain cancers is often associated with the development of radiation-induced cognitive dysfunction (RICD). RICD significantly impacts the quality of life for cancer survivors, highlighting an unmet medical need. Previous human studies revealed a marked reduction in plasma brain-derived neurotrophic factor (BDNF) post-chronic chemotherapy, linking this decline to a substantial cognitive dysfunction among cancer survivors. Moreover, riluzole (RZ)-mediated increased BDNF

Identifiers

PMID39386496
PMCPMC11463616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.