Evidence map›Paper›PMID 39386494›Full record

ArticlebioRxiv : the preprint server for biology2025

Human-specific gene expansions contribute to brain evolution.

Daniela C Soto, José M Uribe-Salazar, Gulhan Kaya, Ricardo Valdarrago, Aarthi Sekar, Nicholas K Haghani, Keiko Hino, Gabriana La, Natasha Ann F Mariano, Cole Ingamells and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Daniela C SotoDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
José M Uribe-SalazarDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
Gulhan KayaDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
Ricardo ValdarragoDepartment of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.
Aarthi SekarDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
Nicholas K HaghaniDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
Keiko HinoDepartment of Cell Biology & Human Anatomy, University of California, Davis, CA 95616, USA.
Gabriana LaDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
Natasha Ann F MarianoDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
Cole IngamellsDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
Aidan BarabanDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
Zoeb JamalDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.
Tychele N TurnerDepartment of Genetics, Washington University School of Medicine, St Louis, MS, 63110, USA.ORCID 0000-0001-8246-6477
Eric D GreenNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Sergi SimóDepartment of Cell Biology & Human Anatomy, University of California, Davis, CA 95616, USA.ORCID 0000-0002-8344-0313
Gerald QuonGenome Center, University of California, Davis, CA 95616, USA.ORCID 0000-0002-1716-0153
Aida M AndrésUCL Genetics Institute, Department of Genetics, Evolution and Environment, University College, London, WC1E 6BT, UK.
Megan Y DennisDepartment of Biochemistry & Molecular Medicine, MIND Institute, University of California, Davis, CA 95616, USA.ORCID 0000-0002-8502-5420

Funding

UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
Postbaccalaureate Research Education Program at UC DavisR25GM116690 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOANNA Chungyen CHIU · 2017 to 2026
$3.7M
Noncoding mutations in neurodevelopmental disordersR01MH126933 · NIMH · WASHINGTON UNIVERSITY · PI Tychele Naomi Turner · 2022 to 2026
$3.6M
The function of duplicated genes in human brain evolution and diseaseDP2MH119424 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2018 to 2018
$2.4M
Linking genetics to cellular behavior and disease via multimodal data integrationDP2MH129987 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI QUON, GERALD · 2021 to 2024
$2.3M
The UC Davis enhanced Molecular, Cellular, and Developmental Biology Training ProgramT32GM153586 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Frederic Louis Chedin, ELVA D DIAZ · 2024 to 2026
$2.3M
Regulation of hippocampal morphogenesis and homeostasis by the E3 ubiquitin ligase CRL5R01NS109176 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SIMO, SERGI · 2019 to 2023
$1.7M
Human gene duplications in neurodevelopment and diseaseR01MH132818 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2023 to 2024
$1.4M
NICHD NIH HHS P50 HD103526NIGMS NIH HHS R25 GM116690NIGMS NIH HHS T32 GM007377NIGMS NIH HHS T32 GM153586NIMH NIH HHS DP2 MH119424NIMH NIH HHS DP2 MH129987NIMH NIH HHS R01 MH126933NIMH NIH HHS R01 MH132818NINDS NIH HHS R01 NS109176Wellcome Trust
6 · The paper itself

Abstract

Duplicated genes expanded in the human lineage likely contributed to brain evolution, yet challenges exist in their discovery due to sequence-assembly errors. We used a complete telomere-to-telomere genome sequence to identify 213 human-specific gene families. From these, 362 paralogs were found in all modern human genomes tested and brain transcriptomes, making them top candidates contributing to human-universal brain features. Choosing a subset of paralogs, long-read DNA sequencing of hundreds of modern humans revealed previously hidden signatures of selection, including for T-cell marker

Indexed as

braincopy-number variationgene duplicationsgene expressionhuman evolutionneurodevelopmentsegmental duplicationssequencingzebrafish

Identifiers

PMID39386494
PMCPMC11463660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.