Evidence map›Paper›PMID 39386462›Full record

ArticlebioRxiv : the preprint server for biology2024

Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells.

Rachel Wellington, Xiaoyi Cheng, Clyde A Campbell, Cole Trapnell, Raquel Espin-Palazon, Brandon Hadland, Sergei Doulatov

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rachel WellingtonDivision of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA.
Xiaoyi ChengDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.
Clyde A CampbellDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.
Cole TrapnellDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Raquel Espin-PalazonDepartment of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, USA.
Brandon HadlandTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sergei DoulatovDivision of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA.

Funding

Development of Innovative Resources to Advance MDS ResearchRC2DK127989 · NIDDK · FRED HUTCHINSON CANCER CENTER · PI Marie Bleakley, Sergei Doulatov · 2023 to 2026
$6.2M
Functional and molecular consequences of SF3B1 mutations in human hematopoietic stem cellsR01HL151651 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Robert K Bradley, Sergei Doulatov · 2020 to 2026
$4.0M
Uncovering epigenetic barriers to hematopoietic stem cell formationDP2HL147126 · NHLBI · UNIVERSITY OF WASHINGTON · PI DOULATOV, SERGEI · 2018 to 2018
$2.3M
The role of lamin B1 in normal and myelodysplastic hematopoiesisR01HL169156 · NHLBI · UNIVERSITY OF WASHINGTON · PI Sergei Doulatov · 2023 to 2026
$2.1M
Molecular dissection of Hematopoietic Stem Cell specification triggered by inflammatory mediatorsR01DK131162 · NIDDK · IOWA STATE UNIVERSITY · PI Raquel Espin Palazon · 2022 to 2026
$2.1M
Dormancy-dependent determination of hematopoietic stem cell fate from hemogenic endotheliumR01HL168110 · NHLBI · FRED HUTCHINSON CANCER CENTER · PI Brandon K Hadland · 2023 to 2026
$1.8M
NHLBI NIH HHS DP2 HL147126NHLBI NIH HHS R01 HL151651NHLBI NIH HHS R01 HL168110NHLBI NIH HHS R01 HL169156NIDDK NIH HHS R01 DK131162NIDDK NIH HHS RC2 DK127989
6 · The paper itself

Abstract

Hematopoietic stem cells (HSCs) arise in embryogenesis from a specialized hemogenic endothelium (HE). In this process, HE cells undergo a unique fate change termed endothelial-to-hematopoietic transition, or EHT. While induced pluripotent stem cells (iPSCs) give rise to HE with robust hemogenic potential, the generation of bona fide HSCs from iPSCs remains a challenge. Here, we map single cell dynamics of EHT during embryoid body differentiation from iPSCs and integrate it with human embryo datasets to identify key transcriptional differences between

Identifiers

PMID39386462
PMCPMC11463665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.