Evidence map›Paper›PMID 39386457›Full record

ArticlebioRxiv : the preprint server for biology2024

Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules

Kyla Mace, Amber Zimmerman, Alessandra Chesi, Fusun Doldur-Balli, Hayle Kim, Erika Almeraya Del Valle, Allan I Pack, Struan F A Grant, Matthew S Kayser

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Amber Zimmerman
Alessandra Chesi
Fusun Doldur-Balli
Hayle Kim
Erika Almeraya Del Valle
Allan I Pack
Struan F A Grant
Matthew S Kayser

Funding

Variant-to-gene mapping for brain related traits and disordersR35HG011959 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI CHESI, ALESSANDRA · 2021 to 2025
$2.4M
A cross-species approach to hypersomnia genetics informed by human GWASR01NS135075 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Alessandra Chesi · 2024 to 2026
$1.4M
NHGRI NIH HHS R35 HG011959NINDS NIH HHS R01 NS135075
6 · The paper itself

Abstract

Idiopathic hypersomnia (IH) is a poorly-understood sleep disorder characterized by excessive daytime sleepiness despite normal nighttime sleep. Combining human genomics with behavioral and mechanistic studies in fish and flies, we uncover a role for

Identifiers

PMID39386457
PMCPMC11463363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.