Evidence map›Paper›PMID 39386432›Full record

ArticlebioRxiv : the preprint server for biology2025

Distinct Neural Representations of Hunger and Thirst in Neonatal Mice before the Emergence of Food- and Water-seeking Behaviors.

David C Wang, Yunming Wu, Conor Mehaffy, Leslie A Espinoza-Campomanes, Fernando Santos-Valencia, Kevin M Franks, Liqun Luo

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

David C WangHoward Hughes Medical Institute.ORCID 0009-0009-1580-5403
Yunming WuHoward Hughes Medical Institute.
Conor MehaffyHoward Hughes Medical Institute.
Leslie A Espinoza-CampomanesHoward Hughes Medical Institute.
Fernando Santos-ValenciaDepartment of Neurobiology, Duke University.
Kevin M FranksDepartment of Neurobiology, Duke University.
Liqun LuoHoward Hughes Medical Institute.ORCID 0000-0001-5467-9264

Funding

Mosaic Analysis with Double Markers in MiceR01NS050835 · NINDS · STANFORD UNIVERSITY · PI LIQUN LUO · 2005 to 2026
$7.3M
NINDS NIH HHS R01 NS050835
6 · The paper itself

Abstract

Hunger and thirst are two fundamental drives for maintaining homeostasis and elicit distinct food- and water-seeking behaviors essential for survival. For neonatal mammals, however, both hunger and thirst are sated by consuming milk from their mother. While distinct neural circuits underlying hunger and thirst drives in the adult brain have been characterized, it is unclear when these distinctions emerge in neonates and what processes may affect their development. Here we show that hypothalamic hunger and thirst regions already exhibit specific responses to starvation and dehydration well before a neonatal mouse can seek food and water separately. At this early age, hunger neurons drive feeding behaviors more than do thirst neurons.

Identifiers

PMID39386432
PMCPMC11463676

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.