Evidence map›Paper›PMID 39386423›Full record

ArticlebioRxiv : the preprint server for biology2024

Genetic analysis of the X-linked Adrenoleukodystrophy

Joshua Manor, Sharayu V Jangam, Hyung-Lok Chung, Pranjali Bhagwat, Jonathan Andrews, Hillary Chester, Shu Kondo, Saurabh Srivastav, Juan Botas, Ann B Moser and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Joshua ManorMetabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.
Sharayu V JangamDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-7389-0890
Hyung-Lok ChungDepartment of Neurology, Houston Methodist Research Institute, Houston, TX, USA.
Pranjali BhagwatDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Jonathan AndrewsDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Hillary ChesterDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Shu KondoTokyo University of Science, Faculty of Advanced Engineering, Department of Biological Science and Technology, Tokyo, Japan.
Saurabh SrivastavDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Juan BotasDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.
Ann B MoserHugo W Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD, USA.
Suzette M HugueninHugo W Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD, USA.
Michael F WanglerDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-5245-5910

Funding

Neuronal Mechanisms of Metabolic and Genetic Defects of the PeroxisomeR01NS107733 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI WANGLER, MICHAEL FRANCIS · 2021 to 2025
$2.3M
NINDS NIH HHS R01 NS107733
6 · The paper itself

Abstract

X-linked adrenoleukodystrophy (X-ALD) is a progressive neurodegenerative disorder caused by a loss-of-function (LOF) mutation in the

Identifiers

PMID39386423
PMCPMC11463603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.