Far cortical locking versus standard locking screw fixation in simulated femoral fractures: A biomechanical meta-analysis.

Introduction: Far cortical locking (FCL) is a concept of locking plate fixation with reduced stiffness and symmetric micromotion to improve callus formation. The goal of our study was to review biomechanical data evaluating FCL plate and screw fixation versus standard locking (SL) plate and screw fixation by analyzing studies of cadaveric and synthetic bone models to draw biomechanical conclusions. Methods: Biomechanical studies that compared FCL and SL plate fixation for simulated femoral fractures were reviewed for construct stiffness, load to failure, axial motion at the near and far cortices, and the difference between near and far cortical axial motion to demonstrate motion symmetry. Results: FCL decreased stiffness by 1.069 kN/mm compared to SL (95 % CI 0.405 to 1.732, p = 0.002). FCL demonstrated greater axial motion than SL in the near cortex by 0.425 mm (95 % CI 0.359 to 0.491, p < 0.001) and in the far cortex by 0.456 mm (95 % CI 0.378 to 0.534, p < 0.001). FCL resulted in symmetric motion with no significant difference between far and near cortices with the far cortex displacing 0.347 mm more than near (95 % CI -0.038 to 0.731, p = 0.78). SL resulted in asymmetric motion favoring the far cortex by 0.270 mm (0.096-0.443, p = 0.002). Construct strength was not significantly different with FCL load to failure 0.367 kN greater than SL (95 % CI -0.762 to 1.496, p = 0.524). Conclusion: FCL screw fixation in femoral fractures achieves the goals of reducing construct stiffness and promoting more symmetric axial motion while maintaining construct strength. These results support the overall biomechanical goals of far cortical locking and should encourage investigation into its effects on clinical and radiographic outcomes.