Evidence map›Paper›PMID 39386090›Full record

ArticleBrain communications2024

Fatigue in early multiple sclerosis: MRI metrics of neuroinflammation, relapse and neurodegeneration.

Rozanna Meijboom, Peter Foley, Niall J J MacDougall, Yair Mina, Elizabeth N York, Agniete Kampaite, Daisy Mollison, Patrick K A Kearns, Nicole White, Michael J Thrippleton and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Network Localization of Fatigue in Multiple Sclerosis.Annals of clinical and translational neurology · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Rozanna MeijboomCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.ORCID https://orcid.org/0000-0003-3346-260X
Peter FoleyCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.ORCID https://orcid.org/0000-0001-7039-2976
Niall J J MacDougallAnne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.
Yair MinaViral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.ORCID https://orcid.org/0000-0003-2311-6623
Elizabeth N YorkCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.ORCID https://orcid.org/0000-0002-4310-8607
Agniete KampaiteCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Daisy MollisonCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Patrick K A KearnsAnne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.
Nicole WhiteCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Michael J ThrippletonCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Katy MurrayAnne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh EH16 4SB, UK.
Maria Del C Valdés HernándezCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.ORCID https://orcid.org/0000-0002-2628-4334
Peter ConnickCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Steven JacobsonViral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
Govind NairTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.
Siddharthan ChandranCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.
Adam D WaldmanCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease affecting the brain and spinal cord. Fatigue is a common disabling symptom from MS onset, however the mechanisms by which underlying disease processes cause fatigue remain unclear. Improved pathophysiological understanding offers potential for improved treatments for MS-related fatigue. MRI provides insights into

Indexed as

fatiguemagnetic resonance imagingmultiple sclerosisneurodegenerationneuroinflammation

Identifiers

PMID39386090
PMCPMC11462441

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.