ArticleClinical transplantation2024
Changes in Medication Adherence Across the Posttransplant Period in Pediatric Organ Transplant Recipients.
Article in Clinical transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Psychosocial challenges faced by children who had a solid organ transplant: adherence, transition, and posttraumatic stress.Current opinion in organ transplantation · 2026Review
- Growth Trajectories of Medication Adherence in Pediatric Organ Transplantation and Their Relationship to Posttransplant Health Outcomes.Transplantation direct · 2026Article
- Neighborhood Deprivation Linked to Medication Level Variability in Liver Transplant Recipients.Clinical transplantation · 2025Article
- Child and adolescent heart and lung post-transplant adherence.JHLT open · 2025Article
- Smartphone addiction as a risk factor for medication non-adherence in renal transplant recipients.Archives of medical science : AMS · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
introductionLimited research has explored immunosuppressant medication adherence over time in pediatric transplant patients, who often struggle with posttransplant regimen adherence, resulting in poor outcomes.
methodsThis study investigated the longitudinal growth in immunosuppressive medication levels following transplantation. Medication level variability index (MLVI) scores from tacrolimus blood levels of pediatric organ transplant recipients at a major medical center were analyzed. Linear mixed effect models (LMEM) assessed individual MLVI change trajectories and predictors of growth, exploring both linear and curvilinear growth patterns posttransplant.
resultsA sample of 181 patients with at least 4 years of MLVI data were analyzed. Growth curve modeling identified the cubic model as the best fit for the quarterly MLVI values, which significantly decreased within the first 2 years posttransplant before stabilizing. Gender significantly predicted MLVI change, with females showing greater MLVI decreases, while age at transplant did not significantly predict changes. Significant variation in MLVI among individual patients was found in all models.
conclusionsThe study demonstrated a significant decrease in MLVI values over time, indicating improved medication adherence in pediatric transplant patients, with females exhibiting more adherent growth patterns than males. Future research should aim to identify pediatric patients at high risk of nonadherence.
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