ArticleClinical endoscopy2025
Efficacy of endoscopic vacuum therapy in esophageal luminal defects: a systematic review and meta-analysis.
Article in Clinical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Endoscopic vacuum-assisted closure for pediatric esophageal perforations: a systematic review and individual patient data meta-analysis.Pediatric surgery international · 2026Pooled it
- EVT-Inspired Simplified Negative-Pressure Nasoesophageal Drainage for Cervical Abscess Secondary to Esophageal Perforation.The American journal of case reports · 2026Article
- Early-Stage Esophago-Mediastinal Fistula After Atrial Fibrillation Radiofrequency Ablation Successfully Treated With Endoscopic Vacuum Therapy.Journal of cardiovascular electrophysiology · 2026Article
- Indigenous endoscopic vacuum-assisted closure therapy for esophageal leaks: A novel technique.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Upper Esophageal Perforation with Cervico-Mediastinal Extension Successfully Treated with Endoluminal Vacuum Therapy: A Case Report Highlighting Inflammatory Marker Dynamics.Life (Basel, Switzerland) · 2026Article
- Recurrent Cervical Esophageal Fistula and Retroesophageal Abscess Following Surgical Management of Zenker's Diverticulum.Journal of clinical medicine · 2026Article
- Interventional Endoscopy for the Management of Post-Surgical Leaks and Fistulas: A Scoping Review.Journal of clinical medicine · 2026Review
- Application of endoscopic vacuum-assisted closure therapy for oesophageal perforation: first case report in East Africa.Journal of cardiothoracic surgery · 2026Article
- Endoscopic vacuum therapy for gastrointestinal transmural defects: clinical outcomes and treatment implications: a retrospective study from Korea.Ewha medical journal · 2026Article
- Endoscopic management for gastrointestinal leaks, perforations, and fistulae: Technical tips and outcomes.World journal of gastrointestinal endoscopy · 2025Review
- Esophageal stenting and endoscopic vacuum therapy for esophageal defects: a systematic review and meta-analysis of observational studies.Annals of medicine and surgery (2012) · 2025Article
- Article
- Endoscopic Vacuum Therapy: When and How to Use It?GE Portuguese journal of gastroenterologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsEndoscopic vacuum-assisted closure (EVAC) is a novel technique used to repair esophageal perforation and leaks. Varying data have been reported on the overall success rate of EVAC. We aimed to conduct a meta-analysis of the available data on the clinical success rate of EVAC.
methodsElectronic databases were searched for publications addressing the efficacy of EVAC in esophageal luminal defects. Pooling was conducted using both fixed and random-effects models. The overall clinical success of EVAC therapy was considered the primary outcome, whereas, overall complication rates, need for adjunct therapy, and mortality were considered secondary outcomes.
resultsIn total, 366 patients were included in the study. On pooled analysis, the mean age was 66 years with 68.32% of patients being men. Overall pooled clinical success rate of EVAC therapy was 87.95%. Upon subgroup analysis, the pooled clinical success rate of postsurgical anastomotic leak and transmural esophageal perforation were found to be 86.57% and 88.89%, respectively. The all-cause hospital mortality was 14% and 4.2% in patients with esophageal perforation and EVAC, respectively.
conclusionsThis study demonstrates that EVAC therapy has a high overall clinical success rate, with low mortality. EVAC therapy seems to be a promising procedure with excellent outcomes in patients with luminal esophageal defects.
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