Evidence map›Paper›PMID 39385460›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2024

Patella fractures are associated with bone fragility - a retrospective study.

Isabella Rosillo, Carmen Germosen, Sanchita Agarwal, Ragyie Rawal, Ivelisse Colon, Mariana Bucovsky, Nayoung Kil, Elizabeth Shane, Marcella Walker

Abstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isabella RosilloDivision of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.
Carmen GermosenDivision of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.
Sanchita AgarwalDivision of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0003-4978-0717
Ragyie RawalDivision of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.
Ivelisse ColonDivision of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.
Mariana BucovskyDivision of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.
Nayoung KilDivision of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.
Elizabeth ShaneDivision of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.
Marcella WalkerDivision of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, United States.ORCID 0000-0002-7205-6527

Funding

VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SCHUPF, NICOLE · 1989 to 2008
$21.7M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Skeletal Microstructure - Racial Differences and Genetic ContributorsR01AR071986 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WALKER, MARCELLA DONOVAN · 2018 to 2022
$2.9M
NIAMS NIH HHS R01 AR071986NIA NIH HHS P01 AG007232NIA NIH HHS R01 AG037212NIHNIH HHS RF1AG054023
6 · The paper itself

Abstract

Patella fractures are not typically considered osteoporotic fractures. We compared bone mineral density (BMD) and microstructure in elderly women from a multiethnic population-based study in New York City with any history of a patella fracture (n = 27) to those without historical fracture (n = 384) and those with an adult fragility forearm fracture (n = 28) using dual energy x-ray absorptiometry (DXA) and high resolution peripheral quantitative computed tomography (HR-pQCT). Compared to those without fracture, women with patella fracture had 6.5% lower areal BMD (aBMD) by DXA only at the total hip (p=.007), while women with forearm fracture had lower aBMD at multiple sites and lower trabecular bone score (TBS), adjusted for age, body mass index, race and ethnicity (all p<.05). By HR-pQCT, adjusted radial total and trabecular (Tb) volumetric BMD (vBMD) and Tb number were 10%-24% lower while Tb spacing was 12-23% higher (all p<.05) in the fracture groups versus women without fracture. Women with a forearm, but not a patella, fracture also had lower adjusted radial cortical (Ct) area and vBMD and 21.8% (p<.0001) lower stiffness vs. women without fracture. At the tibia, the fracture groups had 9.3%-15.7% lower total and Tb vBMD (all p<.05) compared to the non-fracture group. Women with a forearm fracture also had 10.9, and 14.7% lower tibial Ct area and thickness versus those without fracture. Compared to women without fracture, tibial stiffness was 9.9% and 12% lower in the patella and forearm fracture groups, respectively (all p<.05). By HR-pQCT, the patella vs. forearm fracture group had 36% higher radial Tb heterogeneity (p<.05). In summary, women with patella fracture had Tb deterioration by HR-pQCT associated with lower tibial mechanical competence that was similar to those with fragility forearm fracture, a more universally accepted "osteoporotic" fracture. These data suggest patella fractures are associated with skeletal fragility and warrant skeletal evaluation.

Indexed as

Bone DensityFractures, BonePatellaAbsorptiometry, PhotonAgedAged, 80 and overFemaleHumansMiddle AgedPatella FractureRetrospective StudiesTomography, X-Ray Computedforearmfracturemicrostructurepatellastrength

Identifiers

PMID39385460
PMCPMC11638554

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.