Evidence map›Paper›PMID 39385361›Full record

ArticlePsychophysiology2025

Using a virtual reality game to train biofeedback-based regulation under stress conditions.

Lucie Daniel-Watanabe, Benjamin Cook, Grace Leung, Marino Krstulović, Johanna Finnemann, Toby Woolley, Craig Powell, Paul Fletcher

Abstract read
In one paragraph

Article in Psychophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. The A52 Breath Method: A Narrative Review of Breathwork for Mental Health and Stress Resilience.Stress and health : journal of the International Society for the Investigation of Stress · 2025
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucie Daniel-WatanabeDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0009-0001-4055-6666
Benjamin CookDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Grace LeungDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Marino KrstulovićDepartment of Physiology, Development and Neuroscience, University of Cambridge Ringgold Standard Institution, Cambridge, UK.
Johanna FinnemannDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Toby WoolleyNinja Theory Ltd, Cambridge, UK.
Craig PowellDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Paul FletcherDepartment of Psychiatry, University of Cambridge, Cambridge, UK.ORCID 0000-0001-8257-1517

Funding

Bernard Wolfe Health Neuroscience FundDepartment of Health NIHR203312Medical Research Council G0600717NIHR Cambridge Biomedical Research Centre NIHR203312Wellcome Trust 206368Wellcome Trust 206368/Z/17/Z
6 · The paper itself

Abstract

Physiological regulation strategies can be effective in reducing anxiety. However, while these strategies are often learned and practised under low-stress conditions, they are more likely to be required under conditions of high stress. We created virtual reality (VR) biofeedback games to both teach participants a breathing technique and then practise that technique under stress. We present two studies: the first provides a proof of concept, demonstrating that participants can apply the breathing technique during stress, with a significant lowering of both respiration rate and increase in heart rate variability (HRV) under stress (p < .001). The second study explicitly evaluated the effectiveness of training by comparing trained and untrained groups. Training was associated with a significantly greater HRV (p = .008) under stress. In within-group comparisons of HRV during stress compared to a baseline stressor presented before training, the trained group showed a significantly greater increase compared to untrained controls (p = .025). Our results show the feasibility and potential effectiveness of VR-based games for biofeedback training under experimentally applied stress. This may offer the opportunity for clinical techniques to more closely reflect the circumstances under which those techniques will be required.

Indexed as

Biofeedback, PsychologyBreathing ExercisesHeart RateRespiratory RateStress, PsychologicalVideo GamesVirtual RealityAdultFemaleHumansMaleYoung Adultanxietybiofeedbackheart rate variabilityinteroceptionrespirationstress

Identifiers

PMID39385361
PMCPMC7617308

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.