Evidence map›Paper›PMID 39385339›Full record

ArticleThe journal of physical chemistry. B2024

Statistical Coupling Analysis Predicts Correlated Motions in Dihydrofolate Reductase.

Thomas L Kalmer, Christine Mae F Ancajas, Cameron I Cohen, Jade M McDaniel, Abiodun S Oyedele, Hannah L Thirman, Allison S Walker

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Thomas L KalmerDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37240-0002, United States.ORCID 0009-0009-8178-2027
Christine Mae F AncajasDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37240-0002, United States.ORCID 0000-0001-5697-2202
Cameron I CohenDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37240-0002, United States.ORCID 0000-0002-9229-7934
Jade M McDanielDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37240-0002, United States.ORCID 0000-0002-0664-8268
Abiodun S OyedeleDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37240-0002, United States.
Hannah L ThirmanDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37240-7935, United States.
Allison S WalkerDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37240-0002, United States.ORCID 0000-0001-5666-7232

Funding

MOLECULAR BIOPHYSICS TRAINING PROGRAM AT VANDERBILTT32GM008320 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1989 to 2023
$7.9M
Machine learning approaches for the discovery, repurposing, and optimization of natural products with therapeutic potential - Supplement to support grad training of Adrian RussR35GM146987 · NIGMS · VANDERBILT UNIVERSITY · PI Allison Sara Walker · 2022 to 2026
$2.4M
NIGMS NIH HHS R35 GM146987NIGMS NIH HHS T32 GM008320
6 · The paper itself

Abstract

Dihydrofolate reductase (DHFR), due to its universality and the depth with which it has been studied, is a model system in the study of protein dynamics. Myriad previous works have identified networks of residues in positions near to and remote from the active site that are involved in the dynamics. For example, specific mutations on the Met20 loop in

Indexed as

Escherichia coliTetrahydrofolate DehydrogenaseAllosteric RegulationHumansMolecular Dynamics SimulationMutationTetrahydrofolate Dehydrogenase

Identifiers

PMID39385339
PMCPMC11514014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.