Evidence map›Paper›PMID 39385286›Full record

ArticleBMC chemistry2024

Copper-amino acid/Carboxymethyl starch composite for controllable releasing of povidone-iodine.

Moataz Morad, Seraj O Alzahrani, Albandary Almahri, Ibrahim S S Alatawi, Kamelah S Alrashdi, Kholood M Alkhamis, Hatun H Alsharief, Nashwa M El-Metwaly

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Article in BMC chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Moataz MoradDepartment of Chemistry, Faculty of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Seraj O AlzahraniDepartment of Chemistry, College of Science, Taibah University, P. O. Box 344, Madinah, Saudi Arabia.
Albandary AlmahriDepartment of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
Ibrahim S S AlatawiDepartment of Chemistry, College of Science, University of Tabuk, Tabuk, 71474, Saudi Arabia.
Kamelah S AlrashdiDepartment of Chemistry, Al-Qunfudah University College, Umm Al-Qura University, Al-Qunfudah, 1109, Saudi Arabia.
Kholood M AlkhamisDepartment of Chemistry, College of Science, University of Tabuk, Tabuk, 71474, Saudi Arabia.
Hatun H AlshariefDepartment of Chemistry, Faculty of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.
Nashwa M El-MetwalyDepartment of Chemistry, Faculty of Sciences, Umm Al-Qura University, Makkah, Saudi Arabia. n_elmetwaly00@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Povidone-iodine is identified as one of the widely applicable antiseptic reagents for treatment of skin infection and wound healing. Controllable releasing of povidone-iodine is extensively required for healing of chronic wounds. The release of povidone-iodine was systematically studied from the composites based on carboxymethyl starch (CMS). Currently, different ratios from copper precursor and L-aspartic acid (L-AA) were interacted with CMS to obtain Cu-L-AA@CMS composites. Increment the percentage of L-AA was reflected in clustering of dense masses from the desirable composite with highly crystalline/stable structural network. Regardless to pH conditions, Cu-L-AA(30%)@CMS composite showed the highest efficiency for controllable release of povidone-iodine, whereas, the release percentages were estimated to be 58%, 32% and 18% at pH 5, 7 and 9, respectively. The kinetic results revealed the impossibility of povidone-iodine releasing via diffusion/erosion for further support of the hypothesis of releasing via swelling process. Moreover, the release of povidone-iodine using column technique showed that the lowest release was estimated at using high rate of 6 mL/min. Besides the biocompatibility and biodegradability of the prepared Cu-L-AA@CMS composites, it showed the superiority for controllable release of povidone-iodine antiseptic reagent to regulate its beneficial effect in curing of the skin.

Indexed as

CMSControllable releasingCuKineticL-aspartic acidPovidone-iodine

Identifiers

PMID39385286
PMCPMC11465524

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.