Evidence map›Paper›PMID 39385279›Full record

ArticleTrials2024

Concussion Health Improvement Program (CHIP): study protocol for a randomized controlled optimization trial for youth with persistent post-concussive symptoms.

Carolyn A McCarty, Tayler Hennings, Chuan Zhou, Emily F Law, Douglas Zatzick, Sara P D Chrisman

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06036147 (Optimizing Collaborative Care for Youth With Persistent Post-Concussive Symptoms), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06036147 narecruitingnot on this map

Optimizing Collaborative Care for Youth With Persistent Post-Concussive Symptoms

TypeinterventionalSponsorSeattle Children's HospitalRan2023 to 2028Enrolled304ConditionsConcussion, Brain, Brain Injury Traumatic MildArmsConcussion-focused cognitive behavioral therapy, Parent skills training, Care management
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carolyn A McCartyDivision of General Pediatrics, Department of Pediatrics, University of Washington School of Medicine, Seattle, USA. cari.mccarty@seattlechildrens.org.
Tayler HenningsCenter for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, USA.ORCID http://orcid.org/0009-0000-5068-9860
Chuan ZhouCenter for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, USA.
Emily F LawDepartment of Pediatrics, and Department of Psychiatry & Behavioral Sciences, University of Kansas Medical Center, Kansas City, USA.
Douglas ZatzickDepartment of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, USA.
Sara P D ChrismanCenter for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, USA.

Funding

Optimizing Collaborative Care for Youth with Persistent Post-Concussive SymptomsR01HD090230 · NICHD · SEATTLE CHILDREN'S HOSPITAL · PI Sara P.D. Chrisman, CAROLYN A MC CARTY · 2017 to 2026
$5.8M
NICHD NIH HHS R01 HD090230
6 · The paper itself

Abstract

backgroundUp to 1.9 million youth in the USA sustain a concussion each year, and up to 30% experience persistent post-concussive symptoms (PPCS) lasting 1 month or more. PPCS can substantially interfere with social, emotional, and academic functioning. Despite these concerns, few evidence-based treatments are available for youth with PPCS. We previously found effectiveness in treating youth with concussion using a collaborative care intervention that integrates mental health care into a medical model, with improvements in concussive symptoms and quality of life at 1 year. Using the multiphase optimization strategy (MOST) framework, we now aim to assess the contribution of each of the three components that were part of collaborative care: concussion-focused cognitive behavioral therapy (cf-CBT), parenting skills training (PST), and care management (CM).

methodsThe MOST factorial design examines all three intervention components with two levels of each (present or absent), resulting in 8 possible treatment combinations. We will recruit 368 youth with PPCS from 2 geographic locations (Seattle and Dallas), randomizing them to 1 of 8 treatment groups. Youth and/or parents will attend treatment sessions via video conferencing software over 3 months, and complete surveys regarding primary outcomes (concussive symptoms and health-related quality of life) and secondary outcomes (sleep, pain, mood, and parental distress) at 6 weeks and 3, 6, and 12 months. We will also assess potential mediators and moderators to allow for future tailoring and refinement. DISCUSSION: The overarching goal of this investigation is to determine which collaborative care components (delivered individually or in combination) are most effective in treating PPCS in concussion-exposed youth. The investigation will inform mental health screening, intervention, and referral procedures for youth and families following concussion. At the completion of this study, we will have an optimized and refined intervention for youth with PPCS ready for large-scale implementation and dissemination.

trial registrationClinicalTrials.gov NCT06036147. Registered on September 13, 2023.

Indexed as

Brain ConcussionCognitive Behavioral TherapyMulticenter Studies as TopicPost-Concussion SyndromeQuality of LifeRandomized Controlled Trials as TopicAdolescentAge FactorsChildFemaleHumansMaleMental HealthParentingParentsTime FactorsAdolescent healthBrain concussionCase managementCognitive behavioral therapyMental healthPsychosocial interventionRandomized clinical trialSports injury

Identifiers

PMID39385279
PMCPMC11465506

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.