Evidence map›Paper›PMID 39385267›Full record

ReviewDiagnostic pathology2024

Keratin 20 positive SDH-deficient renal cell carcinoma: a case report and literature review.

Shuang-Shuang Dong, Zong-Yue Wang, Xiu-Chun Tian, Cui-Mei Wang, Qing Xu, Chen Xu, Wei Yang, Xue-Wen Gu, Qin Xiao

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diagnostic pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuang-Shuang Dong *Department of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China.
Zong-Yue Wang *Department of Medical Research Centre, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China.
Xiu-Chun TianDepartment of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China.
Cui-Mei WangDepartment of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China.
Qing XuDepartment of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China.
Chen XuDepartment of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China.
Wei YangDepartment of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China.
Xue-Wen GuDepartment of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China.
Qin XiaoDepartment of Pathology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou University, Yangzhou, Jiangsu, 225000, China. 18952726221@163.com.

Funding

the Hospital Key Project Fund of Northern Jiangsu People's Hospital SBKY21004the Jiangsu Key Specialty Fund ZDZKB0018
6 · The paper itself

Abstract

This study aims to broaden the morphological scope of SDH-deficient renal cell carcinoma and to assist clinicians and pathologists in better understanding this entity to prevent misdiagnosis. This study used immunohistochemistry staining and the first-generation sequencing Sanger method for gene detection. It retrospectively analysed the clinical pathology, molecular characteristics, biological behaviour, and treatment information of one case of SDH-deficient renal cell carcinoma. The patient was a 57-year-old female with right back pain for more than 20 days and had no personal or family history of kidney tumours. In addition, the tumour cells had clear boundaries in morphology, and residual normal renal tubules could be seen around them. There were also ossification and adipose tissue around the tumour centre. The tumour cells were arranged in a glandular tubular and cord-like manner. Vacuolar and eosinophilic inclusion bodies could be observed in the cytoplasm. The nucleus was regular, the chromatin distribution was fine, and there were no obvious nucleoli. They were low-grade nuclei. In addition, no atypical mitosis or necrosis could been found. Furthermore, immunohistochemistry staining showed SDHB-negative and keratin 20 -positive tumour. Meanwhile, the first-generation sequencing also pointed out the presence of SDHB gene mutations in the tumour. After 12 months of follow-up, there was no evidence of disease recurrence in the patient. SDH-deficient renal cell carcinoma is a rare tumour associated with SDH gene germline mutations, and suspected cases should undergo SDHB immunohistochemistry staining. Most SDH-deficient renal cell carcinomas have a good prognosis, but undifferentiated cases require long-term follow-up.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsBiomarkers, TumorFemaleHumansImmunohistochemistryMiddle AgedSuccinate DehydrogenaseBiomarkers, TumorSuccinate DehydrogenaseDifferential diagnosisKeratin 20 positiveSDH-deficient renal cell carcinoma

Identifiers

PMID39385267
PMCPMC11462985

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.