Evidence map›Paper›PMID 39385266›Full record

ArticleJournal of the International AIDS Society2024

Preferences for pre-exposure prophylaxis delivery via online pharmacy among potential users in Kenya: a discrete choice experiment.

Enrique M Saldarriaga, Yilin Chen, Michalina A Montaño, Nicholas Thuo, Catherine Kiptinness, Fern Terris-Prestholt, Andy Stergachis, Melissa Latigo Mugambi, Kenneth Ngure, Katrina F Ortblad and 1 more

Abstract read
In one paragraph

Article in Journal of the International AIDS Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Enrique M SaldarriagaThe Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0001-8879-6354
Yilin ChenThe Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, Seattle, Washington, USA.
Michalina A MontañoVaccine and Infectious Diseases Division (VIDD), Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Nicholas ThuoPartners in Health and Research Development, Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya.
Catherine KiptinnessPartners in Health and Research Development, Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya.
Fern Terris-PrestholtDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Andy StergachisThe Comparative Health Outcomes, Policy, and Economics (CHOICE) Institute, University of Washington, Seattle, Washington, USA.
Melissa Latigo MugambiDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0001-8875-5528
Kenneth NgureDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-8062-0933
Katrina F OrtbladPublic Health Science Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-5675-8836
Monisha SharmaDepartment of Global Health, University of Washington, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-7599-1561

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Peer PrEP referral + HIV self-test for PrEP initiation among young Kenyan womenR00MH121166 · NIMH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ORTBLAD, KATRINA FRANCES · 2021 to 2024
$866k
The design and evaluation of strategies to implement HIV prevention interventions for pregnant women in community pharmacy settingsK01MH122326 · NIMH · UNIVERSITY OF WASHINGTON · PI MUGAMBI, MELISSA · 2021 to 2024
$582k
Bill and Melinda Gates Foundation INV 035424Gates Foundation INV-035932Gates Foundation INV-037646Gates Foundation INV-038498NIAID NIH HHS P30 AI027757NIMH NIH HHS K01 MH122326NIMH NIH HHS R00 MH121166
6 · The paper itself

Abstract

introductionOral pre-exposure prophylaxis (PrEP) is highly effective, but coverage remains low in high HIV prevalence settings. Initiating and continuing PrEP remotely via online pharmacies is a promising strategy to expand PrEP uptake, but little is known about potential users' preferences.

methodsWe conducted a discrete choice experiment (DCE) to assess preferences for online pharmacy PrEP services. We partnered with MYDAWA, an online pharmacy in Nairobi, Kenya. Eligibility criteria were: ≥18 years, not known HIV positive, interested in PrEP. The DCE contained four attributes: PrEP eligibility assessment (online self-assessed, guided), HIV test type (provider administered, oral HIV self-test [HIVST], blood-based HIVST), clinical consultation (remote, in-person) and user support options (text messages, phone/video call, email). Additionally, participants indicated whether they were willing to uptake their selected service. The survey was advertised on MYDAWA's website; interested participants met staff in-person at a convenient location to complete the survey from 1 June to 20 November 2022. We used conditional logit modelling with an interaction by current PrEP use to estimate overall preferences and latent class analysis (LCA) to assess preference heterogeneity.

resultsOverall, 772 participants completed the DCE; the mean age was 25 years and 54% were female. Most participants indicated a willingness to acquire online PrEP services, with particularly high demand among PrEP-naive individuals. Overall, participants preferred remote clinical consultation, HIV self-testing, online self-assessment and phone call user support. The LCA identified three subgroups: the "prefer online PrEP with remote components" group (60.3% of the sample) whose preferences aligned with the main analysis, the "prefer online PrEP with in-person components" group (20.7%), who preferred in-person consultation, provider-administered HIV testing, and guided assessment, and the "prefer remote PrEP (18.9%)" group who preferred online PrEP services only if they were remote.

conclusionsOnline pharmacy PrEP is highly acceptable and may expand PrEP coverage to those interested in PrEP but not accessing services. Most participants valued privacy and autonomy, preferring HIVST and remote provider interactions. However, when needing support for questions regarding PrEP, participants preferred phone/SMS contact with a provider. One-fifth of participants preferred online PrEP with in-person components, suggesting that providing multiple options can increase uptake.

Indexed as

HIV InfectionsPre-Exposure ProphylaxisAdolescentAdultAnti-HIV AgentsFemaleHumansKenyaMaleMiddle AgedPatient PreferencePharmaceutical Services, OnlineSurveys and QuestionnairesYoung AdultAnti-HIV Agentsdiscrete choice experimentKenyaonline deliverypharmaciespreferencesPrEP

Identifiers

PMID39385266
PMCPMC11464213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.