ArticleNature2024
Temporally distinct 3D multi-omic dynamics in the developing human brain.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
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Who cites it
41 citing papers in PubMed.
- Article
- Altered Postnatal Chromatin Development in the Nucleus Accumbens Primes Enduring Stress Sensitivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- HiC2Self: Self-supervised denoising for bulk and single-cell Hi-C contact maps.Science advances · 2026Article
- Human body single-cell atlas of three-dimensional genome organization and DNA methylation.Science (New York, N.Y.) · 2026Article
- Single-cell profiling of DNA methylation in autism spectrum disorder prefrontal cortex reveals distinct regulatory and aging signatures.Cell genomics · 2026Article
- Multi-omics and artificial intelligence for precision drug discovery and potential clinical applications.Signal transduction and targeted therapy · 2026Review
- Article
- On the molecular basis of enduring memory in neurons, and cell fate in fibroblasts.Nucleic acids research · 2026Review
- Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging.Nature communications · 2026Article
- Scalable single-cell total RNA sequencing unifies coding and noncoding transcriptomics.Nature biotechnology · 2026Article
- mist: a hierarchical Bayesian framework for detecting differential DNA methylation dynamics in single-cell data.Nature communications · 2026Article
- Distinct cellular DNA methylation mechanisms underlie common and rare genetic risk for brain disorders.bioRxiv : the preprint server for biology · 2026Article
- Postnatal conversion of methylcytosine to hydroxymethylcytosine reconfigures the human neuronal epigenome.bioRxiv : the preprint server for biology · 2026Article
- A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- Boosting the detection of enhancer-promoter loops via normalization methods for chromatin interaction data.Nature communications · 2026Article
- Single-Cell Atlas of Transcription and Chromatin States Reveals Regulatory Programs in the Human Brain.bioRxiv : the preprint server for biology · 2026Article
- Hierarchical Chromatin Rewiring Orchestrates Early Transcriptional Regulation in Mouse Cerebral Cortex Following Focal Ischemia.bioRxiv : the preprint server for biology · 2026Article
- A Single-Cell and Spatial 3D Multi-omic Atlas of Developing Human Basal Ganglia and Inhibitory Neurons.bioRxiv : the preprint server for biology · 2026Article
- Epigenetic regulation of brain development, plasticity, and response to early-life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Partners in plasticity: serotonergic glial interactions in brain circuit remodeling.Frontiers in neuroscience · 2026Review
Corrections and comments
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Authors and funding
30 authors.
Matthew G Heffel *Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Jingtian Zhou *Genomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Yi Zhang *Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-4380-7296
Dong-Sung Lee *Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea.ORCID 0000-0003-3815-7057
Kangcheng Hou *Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.
Oier Pastor-AlonsoDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8075-1768
Kevin D AbuhannaDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-0994-7658
Joseph GalassoDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Colin KernCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Chu-Yi TaiCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Carlos Garcia-PadillaCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Mahsa NafisiDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Yi ZhouDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Anthony D SchmittArima Genomics, Carlsbad, CA, USA.
Terence LiDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Maximilian HaeusslerGenomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.
Brittney WickGenomics Institute, University of California, Santa Cruz, Santa Cruz, CA, USA.
Martin Jinye ZhangRay and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Fangming XieDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Ryan S ZiffraDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Eran A MukamelDepartment of Cognitive Science, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-3203-9535
Eleazar EskinDepartment of Computational Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Tomasz J NowakowskiDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jesse R DixonGene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-6273-2181
Bogdan PasaniucDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-0227-2056
Joseph R EckerGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0001-5799-5895
Quan ZhuCenter for Epigenomics, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-5731-4658
Bogdan BintuDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Mercedes F ParedesDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Mercedes.Paredes@ucsf.edu.ORCID 0000-0003-2503-1447
Chongyuan LuoDepartment of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA. cluo@mednet.ucla.edu.ORCID 0000-0002-8541-0695
Funding
Center for Multiomic Human Brain Cell AtlasUM1MH130994 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI MARIA MARGARITA BEHRENS, Joseph R Ecker · 2022 to 2026
$92.4MThe UCSC Genome BrowserU24HG002371 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Maximilian Haeussler · 2022 to 2026
$17.6MRegulation of Cellular Pathwaysin Human Brain DevelopmentP01NS083513 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FANCY, STEPHEN PHILIP JAMES · 2014 to 2024
$12.6MJoint genomic and statistical analyses of schizophrenia and bipolar to decipher genetic susceptibilityR01MH115676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roel A Ophoff, Bogdan Pasaniuc · 2018 to 2026
$5.9MEpigenomic cell-type classification and regulatory element identification in the human brainU01MH121282 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI BEHRENS, M MARGARITA, ECKER, JOSEPH R · 2019 to 2021
$5.4MSpatiotemporal epigenomic and chromosomal architectural cell atlas of developing human brainsU01MH130995 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Chongyuan Luo, Mercedes Paredes · 2022 to 2026
$4.4MDevelopment of methods for multi-omic analysis of DNA methylation and chromatin architecture in single cellsR01HG010634 · NHGRI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI DIXON, JESSE R, ECKER, JOSEPH R · 2019 to 2022
$4.3MAssessing Genomic, Regulatory and Transcriptional Variation at Single Nuclei Resolution in the Brains of Individuals with Autism Spectrum DisorderR01MH125516 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD KRIEGSTEIN, Tomasz Nowakowski · 2021 to 2026
$3.8MSINGLE-CELL MULTI-OMIC APPROACHES TO MECHANISTICALLY CHARACTERIZE PSYCHIATRIC DISORDER RISK LOCI IN THE HUMAN BRAINR01MH125252 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUO, CHONGYUAN · 2021 to 2025
$3.7MMulti-modal profiling of spatially resolved cell types mediating opioid withdrawalR01DA059602 · NIDA · STANFORD UNIVERSITY · PI Bogdan Bintu, Xiaoke Chen · 2023 to 2026
$3.1MMassively parallel characterization of psychiatric disease associated regulatory elements in defined cell typesU01MH116438 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, POLLARD, KATHERINE S. · 2018 to 2021
$2.7MGyrencephalic Model for Neurodevelopmental Disease and Postnatal Cortical Therapeutic InterventionsDP2NS122550 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PAREDES, MERCEDES · 2020 to 2020
$2.4MNHGRI NIH HHS R01 HG010634NHGRI NIH HHS U24 HG002371NIDA NIH HHS R01 DA059602NIH HHS DP5 OD031878NIMH NIH HHS R01 MH115676NIMH NIH HHS R01 MH125252NIMH NIH HHS R01 MH125516NIMH NIH HHS RF1 MH132662NIMH NIH HHS U01 MH116438NIMH NIH HHS U01 MH121282NIMH NIH HHS U01 MH130995NIMH NIH HHS UM1 MH130994NINDS NIH HHS DP2 NS122550NINDS NIH HHS P01 NS083513NINDS NIH HHS R01 NS123263
Abstract
The human hippocampus and prefrontal cortex play critical roles in learning and cognition
Indexed as
ChromatinDNA MethylationEpigenesis, GeneticHippocampusMultiomicsPrefrontal CortexCell DifferentiationDisease SusceptibilityEpigenomicsFetusHumansInfant, NewbornNeurogliaNeuronsSchizophreniaSingle-Cell AnalysisChromatin
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.