Evidence map›Paper›PMID 39385005›Full record

ArticleThe Journal of antibiotics2024

Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase.

Elyza Aiman Azizah Nur, Keisuke Kobayashi, Rio Tejima, Yosuke Katada, Hiroshi Tomoda, Taichi Ohshiro

Abstract read
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Article in The Journal of antibiotics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elyza Aiman Azizah NurDepartment of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.ORCID 0009-0004-2608-4748
Keisuke KobayashiDepartment of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.ORCID 0000-0001-9580-2484
Rio TejimaDepartment of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Yosuke KatadaDepartment of Microbial Chemistry, School of Pharmacy, Kitasato University, Tokyo, Japan.
Hiroshi TomodaDepartment of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Taichi OhshiroDepartment of Microbial Chemistry, Graduate School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan. ohshirot@pharm.kitasato-u.ac.jp.ORCID 0000-0003-3609-0717

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 18KK0219
6 · The paper itself

Abstract

A new drimane sesquiterpene ester, designated insuetusolate (1), and four reported ones (2-5) were isolated from a culture broth of Aspergillus insuetus BF-1613. The chemical structure of 1 was elucidated by extensive spectroscopic analyses, including MS and NMR. Compound 1 has a drimane-type sesquiterpene core with a 2'E,4'E,6'E-octatrienoate side chain. All these drimane sesquiterpene esters inhibited both sterol O-acyl transferase 1 (SOAT1) and 2 (SOAT2), but exhibited slightly potent inhibition against SOAT1 than SOAT2 with selectivity index (SI) [log (IC

Indexed as

AspergillusEstersPolycyclic SesquiterpenesSesquiterpenesSterol O-AcyltransferaseEnzyme InhibitorsHumansInhibitory Concentration 50Magnetic Resonance SpectroscopyMass SpectrometryMolecular StructureSterol O-Acyltransferase 2drimaneEnzyme InhibitorsEstersPolycyclic SesquiterpenesSesquiterpenesSterol O-Acyltransferasesterol O-acyltransferase 1Sterol O-Acyltransferase 2

Identifiers

PMID39385005

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.